This course is destined to provide biologists with the most important tools in biophysics, in particular concerning structural biology, and advanced direct imaging methods. Thus the course aims at allowing biology students to understand advanced imaging methods well enough to critically evaluate research in these areas, plan own experiments, and fully profit from available resources (for example the PDB). For students in the field of bioscience, this course should also provide a solid basis for their own experimental research, especially through its emphasis of hands-on practical tutorials.