Computational Biology is an advanced and practical course with a hands- on approach to the field of computational biology. The course is recommended for both molecular biologists and computer scientists desiring to understand the major issues concerning analysis of genomes, sequences and learns large-scale modeling of complex systems. Various existing methods will be critically described and the strengths and limitations of each will be discussed. There will be practical assignments utilizing the tools described. Prerequisites include genomics I (B204/CBE209) and genomics II (B204). A final paper will be required for the course that critically and constructively analyzes any area of computational molecular biology, bioinformatics or genomics. The final project may also present a novel application of existing tools or the development of some new or improved method.