Research output per year
Research output per year
Personal profile
Research Interests
Our research interests span from subcellular metabolism to the mechanism of inherited metabolic disease. We aim to 1) discover how a defective lysosome or ER-resident protein contributes to the development of metabolic diseases such as Batten disease 2) Develop molecular tools that allow us to provide cutting-edge knowledge on the ER metabolic composition and better understand their metabolic homeostasis 3) demonstrate novel ER-lysosome contact sites and their functions in cellular homeostasis and 4) develop novel therapeutic strategies and biomarkers for these metabolic diseases. Our experiments are conducted in vivo and in cell culture using several subcellular omics, high-throughput functional genomics, and biochemical techniques.
Education
Chemical Engineering, Postdoctoral Fellow, Stanford University
2022
Biology, Postdoctoral Fellow, Whitehead Institute for Biomedical Research
2019
Genomics and Pathway Biology, M.Sc., University of Edinburgh
2013
Genomics and Pathway Biology, Ph.D., University of Edinburgh
2013
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Research output
- 9 Article
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Studying lysosomal function and dysfunction using LysoIP
Laqtom, N. N., Jan 1 2023, In: Nature Reviews Molecular Cell Biology.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
CLN3 is required for the clearance of glycerophosphodiesters from lysosomes
Laqtom, N. N., Dong, W., Medoh, U. N., Cangelosi, A. L., Dharamdasani, V., Chan, S. H., Kunchok, T., Lewis, C. A., Heinze, I., Tang, R., Grimm, C., Dang Do, A. N., Porter, F. D., Ori, A., Sabatini, D. M. & Abu-Remaileh, M., Sep 29 2022, In: NATURE. 609, 7929, p. 1005-1011 7 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein
Armenta, D. A., Laqtom, N. N., Alchemy, G., Dong, W., Morrow, D., Poltorack, C. D., Nathanson, D. A., Abu-Remalieh, M. & Dixon, S. J., Nov 17 2022, In: Cell Chemical Biology. 29, 11, p. 1588-1600.e7Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
Pedram, K., Laqtom, N. N., Shon, D. J., Di Spiezio, A., Riley, N. M., Saftig, P., Abu-Remaileh, M. & Bertozzi, C. R., Sep 27 2022, In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 119, 39Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration
Vest, R. T., Chou, C. C., Zhang, H., Haney, M. S., Li, L., Laqtom, N. N., Chang, B., Shuken, S., Nguyen, A., Yerra, L., Yang, A. C., Green, C., Tanga, M., Abu-Remaileh, M., Bassik, M. C., Frydman, J., Luo, J. & Wyss-Coray, T., Mar 15 2022, In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 119, 11Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
Nufip1 is a ribosome receptor for starvation-induced ribophagy
Wyant, G. A., Abu-Remaileh, M., Frenkel, E. M., Laqtom, N. N., Dharamdasani, V., Lewis, C. A., Chan, S. H., Heinze, I., Ori, A. & Sabatini, D. M., May 18 2018, In: SCIENCE. 360, 6390, p. 751-758 8 p.Research output: Contribution to journal › Article › peer-review
243 Scopus citations -
Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes
Abu-Remaileh, M., Wyant, G. A., Kim, C., Laqtom, N. N., Abbasi, M., Chan, S. H., Freinkman, E. & Sabatini, D. M., Nov 10 2017, In: SCIENCE. 358, 6364, p. 807-813 7 p.Research output: Contribution to journal › Article › peer-review
398 Scopus citations -
Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo
Rückerl, D., Jenkins, S. J., Laqtom, N. N., Gallagher, I. J., Sutherland, T. E., Duncan, S., Buck, A. H. & Allen, J. E., Sep 13 2012, In: Blood. 120, 11, p. 2307-2316 10 p.Research output: Contribution to journal › Article › peer-review
165 Scopus citations
Press/Media
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Stanford University Reports Findings in Cancer (Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein)
11/14/22
1 item of Media coverage
Press/Media: Press / Media
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What’s In a Lysosome? | Cell And Molecular Biology
09/29/22
1 item of Media coverage
Press/Media: Press / Media
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NICHD Researchers Collaborate With Basic Scientists To Understand Rare, Fatal Childhood Neurological Disorder
09/29/22
1 item of Media coverage
Press/Media: Press / Media
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Item of Interest: NICHD researchers collaborate with basic scientists to understand rare, fatal childhood neurological disorder
09/28/22
1 item of Media coverage
Press/Media: Press / Media
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New method allows scientists to determine all the molecules present in the lysosomes of mice
09/23/22
1 item of Media coverage
Press/Media: Press / Media
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Sifting through cellular recycling centers
09/21/22 → 09/22/22
2 items of Media coverage
Press/Media: Press / Media
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News New Method Improves the Study of Cellular Recycling Centers A new method has been developed that allows scientists to determine all the molecules present in the lysosomes of any cell in mice.
09/22/22
1 item of Media coverage
Press/Media: Press / Media
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Stanford University: Sifting through cellular recycling centers
09/22/22
1 item of Media coverage
Press/Media: Press / Media