Research output per year
Research output per year
Personal profile
Research Overview
Prof. Orlando's lab is interested in investigating the chromatin mediated fundamental mechanisms that control cell identity and plasticity. These include signaling to chromatin regulation and nuclear organization by Polycomb proteins, the role of ncRNA-protein interactions in transcriptional regulation, Epigenomics and how this relates for development, transdifferentiation and adaptation (e.g. Metabolism), in particular in stress conditions.
Furthermore, as part of the mechanistic plastic properties of the genome in response to developmental and environmental cues, Prof. Orlando's lab also investigates the epigenetic regulation of the expression and dynamics of transposable elements and their role in cell differentiation and epigenomic biodiversity.
Key Research Areas
Epigenetics
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education
Ph.D., University of Rome La Sapienza
1989
Award Date: Jan 1 1989
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Behind the scenes: How RNA orchestrates the epigenetic regulation of gene expression
Mangiavacchi, A., Morelli, G. & Orlando, V., Jan 25 2023, In: Frontiers in Cell and Developmental Biology. 11, 1123975.Research output: Contribution to journal › Review article › peer-review
Open Access18 Scopus citations -
Chromatin Immunoprecipitation in the Cnidarian Model System Exaiptasia diaphana
Dix, M. F., Liu, P., Cui, G., Valle, F. D., Orlando, V. & Aranda, M., Mar 2023, In: Journal of Visualized Experiments. 2023, 193, e64817.Research output: Contribution to journal › Article › peer-review
Open Access -
Detecting Cell Compartment-Specific PRC2-RNA Interactions via UV-RIP
Della Valle, F., Liu, P., Morelli, G. & Orlando, V., 2023, Methods in Molecular Biology. Humana Press Inc., p. 31-39 9 p. (Methods in Molecular Biology; vol. 2655).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Dynamic Interactome of PRC2-EZH1 Complex Using Tandem-Affinity Purification and Quantitative Mass Spectrometry
Liu, P., Zhang, H., Della Valle, F. & Orlando, V., 2023, Methods in Molecular Biology. Humana Press Inc., p. 101-116 16 p. (Methods in Molecular Biology; vol. 2655).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
1 Scopus citations -
Epigenetics and Brain Plasticity: Back to Function
Morelli, G., Della Valle, F. & Orlando, V., Jun 7 2023, Contemporary Clinical Neuroscience. Springer International Publishing, p. 237-252 16 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
1 Scopus citations -
Liver and muscle circadian clocks cooperate to support glucose tolerance in mice
Smith, J. G., Koronowski, K. B., Mortimer, T., Sato, T., Greco, C. M., Petrus, P., Verlande, A., Chen, S., Samad, M., Deyneka, E., Mathur, L., Blazev, R., Molendijk, J., Kumar, A., Deryagin, O., Vaca-Dempere, M., Sica, V., Liu, P., Orlando, V. & Parker, B. L. & 7 others, , Jun 27 2023, In: Cell reports. 42, 6, 112588.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Synaptic and transcriptomic features of cortical and amygdala pyramidal neurons predict inefficient fear extinction.
Laricchiuta, D., Gimenez, J., Sciamanna, G., Termine, A., Fabrizio, C., Della Valle, F., Caioli, S., Saba, L., De Bardi, M., Balsamo, F., Panuccio, A., Passarello, N., Mattioni, A., Bisicchia, E., Zona, C., Orlando, V. & Petrosini, L., Aug 31 2023, In: Cell reports. 42, 9, p. 113066Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
TDP-43 Epigenetic Facets and Their Neurodegenerative Implications
Gimenez, J., Spalloni, A., Cappelli, S., Ciaiola, F., Orlando, V., Buratti, E. & Longone, P., Sep 7 2023, In: International journal of molecular sciences. 24, 18, p. 13807Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Prizes
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Honor Order of Merit (Knighthood) from the President of Italian Republic
Orlando, V. (Recipient), 2006
Prize: Award or Honor › Excellence Award
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President of the Italian Society of Biophysics and Molecular Biology (2007 -2013)
Orlando, V. (Recipient), 2007
Prize: Award or Honor › Learned Society
Press/Media
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Investigators at King Abdullah University of Science and Technology (KAUST) Discuss Findings in Genomics and Genetics (Line-1 Rna Triggers Matrix Formation In Bone Cells Via a Pkr-mediated Inflammatory Response)
Zhang, H., Orlando, V., Mangiavacchi, A., Liu, P. & Bensaddek, D.
07/26/24
1 item of Media coverage
Press/Media: Press / Media
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Study Findings from King Abdullah University of Science and Technology (KAUST) Provide New Insights into Nucleoproteins (Chromatin Immunoprecipitation In the Cnidarian Model Exaiptasia Diaphana)
Aranda, M., Orlando, V., Liu, P. & Dix, M. F.
06/5/23
1 item of Media coverage
Press/Media: Press / Media
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Finding an RNA target and tool to fight premature aging
10/4/22
1 item of Media coverage
Press/Media: Press / Media
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Saudi Arabia : RNA-based approach identified for treatment of premature aging and associated diseases
08/23/22
1 item of Media coverage
Press/Media: Press / Media
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Saudi Arabia : RNA-based approach identified for treatment of premature aging and associated diseases
08/23/22
1 item of Media coverage
Press/Media: Press / Media
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Antisense oligonucleotides targeting LINE-1 RNA could be used to treat premature aging
08/17/22
1 item of Media coverage
Press/Media: Press / Media
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RNA-based approach identified for treatment of premature aging and associated diseases
Zhang, H., Orlando, V., Celii, M., Bensaddek, D., Liu, P. & Mangiavacchi, A.
08/16/22
1 item of Media coverage
Press/Media: Press / Media
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RNA-based approach identified for treatment of premature aging and associated diseases
Zhang, H., Orlando, V., Celii, M., Bensaddek, D., Liu, P. & Mangiavacchi, A.
08/16/22
1 item of Media coverage
Press/Media: Press / Media