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1993 …2024

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  • 2024

    PRC2-EZH1 contributes to circadian gene expression by orchestrating chromatin states and RNA polymerase II complex stability

    Liu, P., Nadeef, S., Serag, M. F., Paytuví-Gallart, A., Abadi, M., Della Valle, F., Radío, S., Roda, X., Dilmé Capó, J., Adroub, S., Hosny El Said, N., Fallatah, B., Celii, M., Messa, G. M., Wang, M., Li, M., Tognini, P., Aguilar-Arnal, L., Habuchi, S. & Masri, S. & 2 others, Sassone-Corsi, P. & Orlando, V., 2024, (Accepted/In press) In: EMBO JOURNAL. 43, 23, p. 6052-6075 24 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1 Scopus citations
  • 2023

    Chromatin Immunoprecipitation in the Cnidarian Model System Exaiptasia diaphana

    Dix, M. F., Liu, P., Cui, G., Valle, F. D., Orlando, V. & Aranda, M., Mar 2023, In: Journal of Visualized Experiments. 2023, 193, e64817.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Liver and muscle circadian clocks cooperate to support glucose tolerance in mice

    Smith, J. G., Koronowski, K. B., Mortimer, T., Sato, T., Greco, C. M., Petrus, P., Verlande, A., Chen, S., Samad, M., Deyneka, E., Mathur, L., Blazev, R., Molendijk, J., Kumar, A., Deryagin, O., Vaca-Dempere, M., Sica, V., Liu, P., Orlando, V. & Parker, B. L. & 7 others, Baldi, P., Welz, P. S., Jang, C., Masri, S., Benitah, S. A., Muñoz-Cánoves, P. & Sassone-Corsi, P., Jun 27 2023, In: Cell reports. 42, 6, 112588.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    21 Scopus citations
  • Synaptic and transcriptomic features of cortical and amygdala pyramidal neurons predict inefficient fear extinction.

    Laricchiuta, D., Gimenez, J., Sciamanna, G., Termine, A., Fabrizio, C., Della Valle, F., Caioli, S., Saba, L., De Bardi, M., Balsamo, F., Panuccio, A., Passarello, N., Mattioni, A., Bisicchia, E., Zona, C., Orlando, V. & Petrosini, L., Aug 31 2023, In: Cell reports. 42, 9, p. 113066

    Research output: Contribution to journalArticlepeer-review

    5 Scopus citations
  • TDP-43 Epigenetic Facets and Their Neurodegenerative Implications

    Gimenez, J., Spalloni, A., Cappelli, S., Ciaiola, F., Orlando, V., Buratti, E. & Longone, P., Sep 7 2023, In: International journal of molecular sciences. 24, 18, p. 13807

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations
  • 2022

    LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes

    Valle, F. D., Reddy, P., Yamamoto, M., Liu, P., Saera-Vila, A., Bensaddek, D., Zhang, H., Martinez, J. P., Abassi, L., Celii, M., Ocampo, A., Delicado, E. N., Mangiavacchi, A., Cigliano, R. A., Esteban, C. R., Horvath, S., Belmonte, J. C. I. & Orlando, V., Aug 10 2022, In: Science Translational Medicine. 14, 657, eabl6057.

    Research output: Contribution to journalArticlepeer-review

    53 Scopus citations
  • Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits

    Termine, A., Fabrizio, C., Gimenez, J., Panuccio, A., Balsamo, F., Passarello, N., Caioli, S., Saba, L., De Bardi, M., Della Valle, F., Orlando, V., Petrosini, L. & Laricchiuta, D., Mar 1 2022, In: International journal of molecular sciences. 23, 5, 2538.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1 Scopus citations
  • 2021

    Ago1 controls myogenic differentiation by regulating eRNA-mediated CBP-guided epigenome reprogramming

    Fallatah, B., Shuaib, M., Adroub, S., Paytuví-Gallart, A., Della Valle, F., Nadeef, S. S., Lanzuolo, C. & Orlando, V., Nov 2021, In: Cell Reports. 37, 9, p. 110066

    Research output: Contribution to journalArticlepeer-review

    14 Scopus citations
  • Open Access
    15 Scopus citations
  • Malat-1-PRC2-EZH1 interaction supports adaptive oxidative stress dependent epigenome remodeling in skeletal myotubes

    El Said, N. H., Della Valle, F., Liu, P., Paytuví-Gallart, A., Adroub, S., Gimenez, J. & Orlando, V., Oct 2021, In: Cell Death and Disease. 12, 10, 850.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    10 Scopus citations
  • Optogenetic Stimulation of Prelimbic Pyramidal Neurons Maintains Fear Memories and Modulates Amygdala Pyramidal Neuron Transcriptome.

    Laricchiuta, D., Sciamanna, G., Gimenez, J., Termine, A., Fabrizio, C., Caioli, S., Balsamo, F., Panuccio, A., De Bardi, M., Saba, L., Passarello, N., Cutuli, D., Mattioni, A., Zona, C., Orlando, V. & Petrosini, L., Jan 20 2021, In: International journal of molecular sciences. 22, 2, p. 810

    Research output: Contribution to journalArticlepeer-review

    7 Scopus citations
  • 2020

    Functional annotation of human long noncoding RNAs via molecular phenotyping.

    Ramilowski, J. A., Yip, C. W., Agrawal, S., Chang, J.-C., Ciani, Y., Kulakovskiy, I. V., Mendez, M., Ooi, J. L. C., Ouyang, J. F., Parkinson, N., Petri, A., Roos, L., Severin, J., Yasuzawa, K., Abugessaisa, I., Akalin, A., Antonov, I. V., Arner, E., Bonetti, A. & Bono, H. & 96 others, Borsari, B., Brombacher, F., Cameron, C. J. F., Cannistraci, C. V., Cardenas, R., Cardon, M., Chang, H., Dostie, J., Ducoli, L., Favorov, A., Fort, A., Garrido, D., Gil, N., Gimenez, J., Guler, R., Handoko, L., Harshbarger, J., Hasegawa, A., Hasegawa, Y., Hashimoto, K., Hayatsu, N., Heutink, P., Hirose, T., Imada, E. L., Itoh, M., Kaczkowski, B., Kanhere, A., Kawabata, E., Kawaji, H., Kawashima, T., Kelly, S. T., Kojima, M., Kondo, N., Koseki, H., Kouno, T., Kratz, A., Kurowska-Stolarska, M., Kwon, A. T. J., Leek, J., Lennartsson, A., Lizio, M., López-Redondo, F., Luginbühl, J., Maeda, S., Makeev, V. J., Marchionni, L., Medvedeva, Y. A., Minoda, A., Müller, F., Muñoz-Aguirre, M., Murata, M., Nishiyori, H., Nitta, K. R., Noguchi, S., Noro, Y., Nurtdinov, R., Okazaki, Y., Orlando, V., Paquette, D., Parr, C. J. C., Rackham, O. J. L., Rizzu, P., Sánchez Martinez, D. F., Sandelin, A., Sanjana, P., Semple, C. A. M., Shibayama, Y., Sivaraman, D. M., Suzuki, T., Szumowski, S. C., Tagami, M., Taylor, M. S., Terao, C., Thodberg, M., Thongjuea, S., Tripathi, V., Ulitsky, I., Verardo, R., Vorontsov, I. E., Yamamoto, C., Young, R. S., Baillie, J. K., Forrest, A. R. R., Guigó, R., Hoffman, M. M., Hon, C. C., Kasukawa, T., Kauppinen, S., Kere, J., Lenhard, B., Schneider, C., Suzuki, H., Yagi, K., de Hoon, M. J. L., Shin, J. W. & Carninci, P., Jul 29 2020, In: Genome research.

    Research output: Contribution to journalArticlepeer-review

    105 Scopus citations
  • RADICL-seq identifies general and cell type–specific principles of genome-wide RNA-chromatin interactions

    Bonetti, A., Agostini, F., Suzuki, A. M., Hashimoto, K., Pascarella, G., Gimenez, J., Roos, L., Nash, A. J., Ghilotti, M., Cameron, C. J. F., Valentine, M., Medvedeva, Y. A., Noguchi, S., Agirre, E., Kashi, K., Samudyata, Luginbühl, J., Cazzoli, R., Agrawal, S. & Luscombe, N. M. & 9 others, Blanchette, M., Kasukawa, T., Hoon, M. D., Arner, E., Lenhard, B., Plessy, C., Castelo-Branco, G., Orlando, V. & Carninci, P., Feb 24 2020, In: Nature Communications. 11, 1

    Research output: Contribution to journalArticlepeer-review

    101 Scopus citations
  • Transdifferentiation of Mouse Embryonic Fibroblasts into Dopaminergic Neurons Reactivates LINE-1 Repetitive Elements

    Della Valle, F., Thimma, M. P., Caiazzo, M., Pulcrano, S., Celii, M., Adroub, S. A., Liu, P., Alanis-Lobato, G., Broccoli, V. & Orlando, V., Jan 14 2020, In: Stem Cell Reports. 14, 1, p. 60-74 15 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    16 Scopus citations
  • 2019

    Nuclear AGO1 Regulates Gene Expression by Affecting Chromatin Architecture in Human Cells.

    Shuaib, M., Parsi, K. M., Thimma, M., Adroub, S., Kawaji, H., Seridi, L., Ghosheh, Y., Fort, A., Fallatah, B., Ravasi, T., Carninci, P. & Orlando, V., Oct 21 2019, In: Cell systems. 9, 5, p. 446-458.e6 457999555 p.

    Research output: Contribution to journalArticlepeer-review

    22 Scopus citations
  • Ubiquitin ligases HUWE1 and NEDD4 cooperatively control signal-dependent PRC2-Ezh1α/β-mediated adaptive stress response pathway in skeletal muscle cells

    Liu, P., Shuaib, M., Zhang, H., Nadeef, S. & Orlando, V., Dec 19 2019, In: Epigenetics and Chromatin. 12, 1, 78.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    15 Scopus citations
  • 2018

    Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks

    Dyar, K. A., Lutter, D., Artati, A., Ceglia, N. J., Liu, Y., Armenta, D., Jastroch, M., Schneider, S., de Mateo, S., Cervantes, M., Abbondante, S., Tognini, P., Orozco-Solis, R., Kinouchi, K., Wang, C., Swerdloff, R., Nadeef, S., Masri, S., Magistretti, P. & Orlando, V. & 7 others, Borrelli, E., Uhlenhaut, N. H., Baldi, P., Adamski, J., Tschöp, M. H., Eckel-Mahan, K. & Sassone-Corsi, P., Sep 6 2018, In: Cell. 174, 6, p. 1571-1585.e11

    Research output: Contribution to journalArticlepeer-review

    Open Access
    255 Scopus citations
  • Open Access
    23 Scopus citations
  • 2017

    A cytosolic Ezh1 isoform modulates a PRC2–Ezh1 epigenetic adaptive response in postmitotic cells

    Bodega, B., Marasca, F., Ranzani, V., Cherubini, A., Valle, F. D., Neguembor, M. V., Wassef, M., Zippo, A., Lanzuolo, C., Pagani, M. & Orlando, V., Mar 27 2017, In: Nature Structural & Molecular Biology. 24, 5, p. 444-452 9 p.

    Research output: Contribution to journalArticlepeer-review

    34 Scopus citations
  • FANTOM5 CAGE profiles of human and mouse samples

    Noguchi, S., Arakawa, T., Fukuda, S., Furuno, M., Hasegawa, A., Hori, F., Ishikawa-Kato, S., Kaida, K., Kaiho, A., Kanamori-Katayama, M., Kawashima, T., Sakai, M., Simon, C., Suzuki, N., Tagami, M., Watanabe, S., Yoshida, S., Arner, P., Axton, R. A. & Babina, M. & 158 others, Baillie, J. K., Mummery, C. L., Barnett, T. C., Beckhouse, A. G., Blumenthal, A., Bodega, B., Bonetti, A., Briggs, J., Brombacher, F., Carlisle, A. J., Clevers, H. C., Davis, C. A., Nakachi, Y., Detmar, M., Dohi, T., Edge, A. S. B., Edinger, M., Ehrlund, A., Ekwall, K., Endoh, M., Enomoto, H., Eslami, A., Fagiolini, M., Nakahara, F., Fairbairn, L., Farach-Carson, M. C., Faulkner, G. J., Ferrai, C., Fisher, M. E., Forrester, L. M., Fujita, R., Furusawa, J.-I., Geijtenbeek, T. B., Gingeras, T., Nakamura, T., Goldowitz, D., Guhl, S., Guler, R., Gustincich, S., Ha, T. J., Hamaguchi, M., Hara, M., Hasegawa, Y., Herlyn, M., Heutink, P., Nakamura, Y., Hitchens, K. J., Hume, D. A., Ikawa, T., Orlando, V., Kai, C., Kawamoto, H., Kawamura, Y. I., Kempfle, J. S., Kenna, T. J., Kere, J., Nozaki, T., Khachigian, L. M., Kitamura, T., Klein, S., Klinken, S. P., Knox, A. J., Kojima, S., Koseki, H., Koyasu, S., Lee, W., Lennartsson, A., Ogishima, S., Mackay-sim, A., Mejhert, N., Mizuno, Y., Morikawa, H., Morimoto, M., Moro, K., Morris, K. J., Motohashi, H., Ohkura, N., Ohno, H., Ohshima, M., Kojima, M., Okada-Hatakeyama, M., Okazaki, Y., Orlando, V., Ovchinnikov, D. A., Passier, R., Patrikakis, M., Pombo, A., Pradhan-Bhatt, S., Qin, X.-Y., Rehli, M., Kubosaki, A., Rizzu, P., Roy, S., Sajantila, A., Sakaguchi, S., Sato, H., Satoh, H., Savvi, S., Saxena, A., Schmidl, C., Schneider, C., Manabe, R.-I., Schulze-Tanzil, G. G., Schwegmann, A., Sheng, G., Shin, J. W., Sugiyama, D., Sugiyama, T., Summers, K. M., Takahashi, N., Takai, J., Tanaka, H., Murata, M., Tatsukawa, H., Tomoiu, A., Toyoda, H., van de Wetering, M., van den Berg, L. M., Verardo, R., Vijayan, D., Wells, C. A., Winteringham, L. N., Wolvetang, E., Nagao-Sato, S., Yamaguchi, Y., Yamamoto, M., Yanagi-Mizuochi, C., Yoneda, M., Yonekura, Y., Zhang, P. G., Zucchelli, S., Abugessaisa, I., Arner, E., Harshbarger, J., Nakazato, K., Kondo, A., Lassmann, T., Lizio, M., Sahin, S., Sengstag, T., Severin, J., Shimoji, H., Suzuki, M., Suzuki, H., Kawai, J., Ninomiya, N., Kondo, N., Itoh, M., Daub, C. O., Kasukawa, T., Kawaji, H., Carninci, P., Forrest, A. R. R., Hayashizaki, Y., Nishiyori-Sueki, H., Noma, S., Saijyo, E. & Saka, A., Aug 29 2017, In: Scientific data. 4, 1

    Research output: Contribution to journalArticlepeer-review

    Open Access
    172 Scopus citations
  • Gathering by the Red Sea highlights links between environment and epigenetics

    Li, M., Borrelli, E., Magistretti, P. J., Izpisua Belmonte, J. C., Sassone-Corsi, P. & Orlando, V., Jun 6 2017, In: Nature Structural & Molecular Biology. 24, 6, p. 491-491 1 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • 2016

    Characterization of piRNAs across postnatal development in mouse brain

    Ghosheh, Y., Seridi, L., Ryu, T. W., Takahashi, H., Orlando, V., Carninci, P. & Ravasi, T., Apr 26 2016, In: Scientific Reports. 6, 1

    Research output: Contribution to journalArticlepeer-review

    Open Access
    31 Scopus citations
  • 2015

    Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

    FANTOM Consortium, Feb 27 2015, In: SCIENCE. 347, 6225, p. 1010-1014 5 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    443 Scopus citations
  • 2014

    A promoter-level mammalian expression atlas

    Forest, A. R. R., Kawaji, H., Rehli, M., Baillie, J. K., De Hoon, M. J. L., Haberle, V., Lassmann, T., Kulakovskiy, I. V., Lizio, M., Itoh, M., Andersson, R., Iida, K., Ikawa, T., Jankovic, B. R., Jia, H., Joshi, A. M., Jurman, G., Kaczkowski, B., Kai, C. & Kaida, K. & 241 others, Kaiho, A., Mungall, C. J., Kajiyama, K., Kanamori-Katayama, M., Kasianov, A. S., Kasukawa, T., Katayama, S., Kato, S., Kawaguchi, S., Kawamoto, H., Kawamura, Y. I., Kawashima, T., Meehan, T. F., Kempfle, J. S., Kenna, T. J., Kere, J., Khachigian, L. M., Kitamura, T., Klinken, S. P., Knox, A., Kojima, M., Kojima, S., Kondo, N., Schmeier, S., Koseki, H., Koyasu, S., Krampitz, S., Kubosaki, A., Kwon, A. T., Laros, J. F. J., Lee, W., Lennartsson, A., Li, K., Lilje, B., Bertin, N., Lipovich, L., MacKay-Sim, A., Manabe, R., Mar, J., Marchand, B., Mathelier, A., Mejhert, N., Meynert, A. M., Mizuno, Y., De Morais, D. A. L., Jørgensen, M. C., Morikawa, H., Morimoto, M., Moro, K., Motakis, E., Motohashi, H., Mummery, C. L., Murata, M., Nagao-Sato, S., Nakachi, Y., Nakahara, F., Dimont, E., Nakamura, T., Nakamura, Y., Nakazato, K., Van Nimwegen, E., Ninomiya, N., Nishiyori, H., Noma, S., Nozaki, T., Ogishima, S., Ohkura, N., Arner, E., Ohmiya, H., Ohno, H., Ohshima, M., Okada-Hatakeyama, M., Okazaki, Y., Orlando, V., Ovchinnikov, D. A., Pain, A., Passier, R. C. J. J., Patrikakis, M., Schmidl, C., Persson, H. A., Piazza, S., Prendergast, J. G. D., Rackham, O. J. L., Ramilowski, J. A., Rashid, M., Ravasi, T., Rizzu, P., Roncador, M., Roy, S., Schaefer, U., Rye, M. B., Saijyo, E., Sajantila, A., Saka, A., Sakaguchi, S., Sakai, M., Sato, H., Satoh, H., Savvi, S., Saxena, A., Medvedeva, Y., Schneider, C. H., Schultes, E. A., Schulze-Tanzil, G. G., Schwegmann, A., Sengstag, T., Sheng, G., Shimoji, H., Shimoni, Y., Shin, J. W., Simon, C. M., Plessy, C., Sugiyama, D., Sugiyama, T., Suzuki, M., Suzuki, N., Swoboda, R. K., 't Hoen, P. A. C., Tagami, M., Tagami, N., Takai, J., Tanaka, H., Vitezic, M., Tatsukawa, H., Tatum, Z., Thompson, M., Toyoda, H., Toyoda, T., Valen, E., Van De Wetering, M. L., Van Den Berg, L. M., Verardo, R., Vijayan, D., Severin, J. M., Vorontsov, I. E., Wasserman, W. W., Watanabe, S., Wells, C. A., Winteringham, L. N., Wolvetang, E. J., Wood, E. J., Yamaguchi, Y., Yamamoto, M., Yoneda, M., Semple, C. A. M., Yonekura, Y., Yoshida, S., Zabierowski, S. E., Zhang, P., Zhao, X., Zucchelli, S., Summers, K. M., Suzuki, H., Daub, C. O., Kawai, J., Ishizu, Y., Heutink, P., Hide, W., Freeman, T. C., Lenhard, B., Bajic, V. B., Taylor, M. S., Makeev, V. J., Sandelin, A., Hume, D. A., Carninci, P., Young, R. S., Hayashizaki, Y. Y., Francescatto, M., Alam, I., Albanese, D., Altschule, G. M., Arakawa, T., Archer, J. A. C., Arner, P., Babina, M., Rennie, S., Balwierz, P. J., Beckhouse, A. G., Pradhan-Bhatt, S., Blake, J. A., Blumenthal, A., Bodega, B., Bonetti, A., Briggs, J. A., Brombacher, F., Burroughs, A. M., Califano, A. C., Cannistraci, C., Carbajo, D., Chen, Y., Chierici, M., Ciani, Y., Clevers, H. C., Dalla, E., Davis, C. A., Detmar, M. J., Diehl, A. D., Dohi, T., Drabløs, F., Edge, A. S. B., Edinger, M. G., Ekwall, K., Endoh, M., Enomoto, H., Fagiolini, M., Fairbairn, L. R., Fang, H., Farach-Carson, M. C., Faulkner, G. J., Favorov, A. V., Fisher, M. E., Frith, M. C., Fujita, R., Fukuda, S., Furlanello, C., Furuno, M., Furusawa, J., Geijtenbeek, T. B. H., Gibson, A. P., Gingeras, T. R., Goldowitz, D., Gough, J., Guhl, S., Guler, R., Gustincich, S., Ha, T., Hamaguchi, M., Hara, M., Harbers, M., Harshbarger, J., Hasegawa, A., Hasegawa, Y., Hashimoto, T., Herlyn, M. F., Hitchens, K. J., Sui, S. J. H., Hofmann, O. M., Hoof, I., Hori, F. & Huminiecki, Ł. B., Mar 27 2014, In: Nature. 507, 7493, p. 462-470 9 p.

    Research output: Contribution to journalArticlepeer-review

    1435 Scopus citations
  • Epigenetics in brain function

    West, A. E. & Orlando, V., Apr 2014, In: Neuroscience. 264, p. 1-3 3 p.

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations
  • Repetitive elements dynamics in cell identity programming, maintenance and disease

    Bodega, B. & Orlando, V., Dec 2014, In: Current Opinion in Cell Biology. 31, p. 67-73 7 p.

    Research output: Contribution to journalArticlepeer-review

    32 Scopus citations
  • 2013

    PcG-Mediated Higher-Order Chromatin Structures Modulate Replication Programs at the Drosophila BX-C

    Lo Sardo, F., Lanzuolo, C., Comoglio, F., De Bardi, M., Paro, R. & Orlando, V., Feb 2013, In: PLOS Genetics. 9, 2, e1003283.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    15 Scopus citations
  • RNA-Interference Components Are Dispensable for Transcriptional Silencing of the Drosophila Bithorax-Complex

    Cernilogar, F. M., Burroughs, A. M., Lanzuolo, C., Breiling, A., Imhof, A. & Orlando, V., Jun 13 2013, In: PLoS ONE. 8, 6, p. e65740

    Research output: Contribution to journalArticlepeer-review

    Open Access
    7 Scopus citations
  • 2012

    Concerted epigenetic signatures inheritance at PcG targets through replication

    Lanzuolo, C., Lo Sardo, F. & Orlando, V., Apr 1 2012, In: Cell Cycle. 11, 7, p. 1296-1300 5 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    16 Scopus citations
  • 2011

    Chromatin-associated RNA interference components contribute to transcriptional regulation in Drosophila

    Cernilogar, F. M., Onorati, M. C., Kothe, G. O., Burroughs, A. M., Parsi, K. M., Breiling, A., Sardo, F. L., Saxena, A., Miyoshi, K., Siomi, H., Siomi, M. C., Carninci, P., Gilmour, D. S., Corona, D. F. V. & Orlando, V., Dec 15 2011, In: NATURE. 480, 7377, p. 391-395 5 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    186 Scopus citations
  • Chromatin regulated interchange between polycomb repressive complex 2 (PRC2)-Ezh2 and PRC2-Ezh1 complexes controls myogenin activation in skeletal muscle cells

    Stojic, L., Jasencakova, Z., Prezioso, C., Stützer, A., Bodega, B., Pasini, D., Klingberg, R., Mozzetta, C., Margueron, R., Puri, P., Schwarzer, D., Helin, K., Fischle, W. & Orlando, V., 2011, In: Epigenetics and Chromatin. 4, 1, 16.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    112 Scopus citations
  • Enhancer of zeste homolog 2 overexpression has a role in the development of anaplastic thyroid carcinomas

    Borbone, E., Troncone, G., Ferraro, A., Jasencakova, Z., Stojic, L., Esposito, F., Hornig, N., Fusco, A. & Orlando, V., Apr 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 4, p. 1029-1038 10 p.

    Research output: Contribution to journalArticlepeer-review

    64 Scopus citations
  • PcG complexes set the stage for epigenetic inheritance of gene silencing in early S phase before replication

    Lanzuolo, C., Sardo, F. L., Diamantini, A. & Orlando, V., Nov 2011, In: PLOS Genetics. 7, 11, e1002370.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    48 Scopus citations
  • The DNA repair complex Ku70/86 modulates Apaf1 expression upon DNA damage

    De Zio, D., Bordi, M., Tino, E., Lanzuolo, C., Ferraro, E., Mora, E., Ciccosanti, F., Fimia, G. M., Orlando, V. & Cecconi, F., Mar 2011, In: Cell Death and Differentiation. 18, 3, p. 516-527 12 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    22 Scopus citations
  • 2010

    Linking promoters to functional transcripts in small samples with nanoCAGE and CAGEscan

    Plessy, C., Bertin, N., Takahashi, H., Simone, R., Salimullah, M., Lassmann, T., Vitezic, M., Severin, J., Olivarius, S., Lazarevic, D., Hornig, N., Orlando, V., Bell, I., Gao, H., Dumais, J., Kapranov, P., Wang, H., Davis, C. A., Gingeras, T. R. & Kawai, J. & 4 others, Daub, C. O., Hayashizaki, Y., Gustincich, S. & Carninci, P., Jul 2010, In: Nature Methods. 7, 7, p. 528-534 7 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    131 Scopus citations
  • 2009

    The regulated retrotransposon transcriptome of mammalian cells

    Faulkner, G. J., Kimura, Y., Daub, C. O., Wani, S., Plessy, C., Irvine, K. M., Schroder, K., Cloonan, N., Steptoe, A. L., Lassmann, T., Waki, K., Hornig, N., Arakawa, T., Takahashi, H., Kawai, J., Forrest, A. R. R., Suzuki, H., Hayashizaki, Y., Hume, D. A. & Orlando, V. & 2 others, Grimmond, S. M. & Carninci, P., May 2009, In: Nature Genetics. 41, 5, p. 563-571 9 p.

    Research output: Contribution to journalArticlepeer-review

    644 Scopus citations
  • The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

    Suzuki, H., Forrest, A. R. R., Van Nimwegen, E., Daub, C. O., Balwierz, P. J., Irvine, K. M., Lassmann, T., Ravasi, T., Hasegawa, Y., De Hoon, M. J. L., Katayama, S., Schroder, K., Carninci, P., Tomaru, Y., Kanamori-Katayama, M., Kubosaki, A., Akalin, A., Ando, Y., Arner, E. & Asada, M. & 140 others, Asahara, H., Bailey, T., Bajic, V. B., Bauer, D., Beckhouse, A. G., Bertin, N., Björkegren, J., Brombacher, F., Bulger, E., Chalk, A. M., Chiba, J., Cloonan, N., Dawe, A., Dostie, J., Engström, P. G., Essack, M., Faulkner, G. J., Fink, J. L., Fredman, D., Fujimori, K., Furuno, M., Gojobori, T., Gough, J., Grimmond, S. M., Gustafsson, M., Hashimoto, M., Hashimoto, T., Hatakeyama, M., Heinzel, S., Hide, W., Hofmann, O., Hörnquist, M., Huminiecki, L., Ikeo, K., Imamoto, N., Inoue, S., Inoue, Y., Ishihara, R., Iwayanagi, T., Jacobsen, A., Kaur, M., Kawaji, H., Kerr, M. C., Kimura, R., Kimura, S., Kimura, Y., Kitano, H., Koga, H., Kojima, T., Kondo, S., Konno, T., Krogh, A., Kruger, A., Kumar, A., Lenhard, B., Lennartsson, A., Lindow, M., Lizio, M., MacPherson, C., Maeda, N., Maher, C. A., Maqungo, M., Mar, J., Matigian, N. A., Matsuda, H., Mattick, J. S., Meier, S., Miyamoto, S., Miyamoto-Sato, E., Nakabayashi, K., Nakachi, Y., Nakano, M., Nygaard, S., Okayama, T., Okazaki, Y., Okuda-Yabukami, H., Orlando, V., Otomo, J., Pachkov, M., Petrovsky, N., Plessy, C., Quackenbush, J., Radovanovic, A., Rehli, M., Saito, R., Sandelin, A., Schmeier, S., Schönbach, C., Schwartz, A. S., Semple, C. A., Sera, M., Severin, J., Shirahige, K., Simons, C., St. Laurent, G., Suzuki, M., Suzuki, T., Sweet, M. J., Taft, R. J., Takeda, S., Takenaka, Y., Tan, K., Taylor, M. S., Teasdale, R. D., Tegnér, J., Teichmann, S., Valen, E., Wahlestedt, C., Waki, K., Waterhouse, A., Wells, C. A., Winther, O., Wu, L., Yamaguchi, K., Yanagawa, H., Yasuda, J., Zavolan, M., Hume, D. A., Arakawa, T., Fukuda, S., Imamura, K., Kai, C., Kaiho, A., Kawashima, T., Kawazu, C., Kitazume, Y., Kojima, M., Miura, H., Murakami, K., Murata, M., Ninomiya, N., Nishiyori, H., Noma, S., Ogawa, C., Sano, T., Simon, C., Tagami, M., Takahashi, Y., Kawai, J. & Hayashizaki, Y., May 2009, In: Nature Genetics. 41, 5, p. 553-562 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    360 Scopus citations
  • Tiny RNAs associated with transcription start sites in animals

    Taft, R. J., Glazov, E. A., Cloonan, N., Simons, C., Stephen, S., Faulkner, G. J., Lassmann, T., Forrest, A. R. R., Grimmond, S. M., Schroder, K., Irvine, K., Arakawa, T., Nakamura, M., Kubosaki, A., Hayashida, K., Kawazu, C., Murata, M., Nishiyori, H., Fukuda, S. & Kawai, J. & 7 others, Daub, C. O., Hume, D. A., Suzuki, H., Orlando, V., Carninci, P., Hayashizaki, Y. & Mattick, J. S., May 2009, In: Nature Genetics. 41, 5, p. 572-578 7 p.

    Research output: Contribution to journalArticlepeer-review

    307 Scopus citations
  • 2007

    Noncoding RNA synthesis and loss of polycomb group repression accompanies the colinear activation of the human HOXA cluster

    Sessa, L., Breiling, A., Lavorgna, G., Silvestri, L., Casari, G. & Orlando, V., Feb 2007, In: RNA. 13, 2, p. 223-239 17 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    112 Scopus citations
  • Polycomb response elements mediate the formation of chromosome higher-order structures in the bithorax complex

    Lanzuolo, C., Roure, V., Dekker, J., Bantignies, F. & Orlando, V., Oct 2007, In: Nature Cell Biology. 9, 10, p. 1167-1174 8 p.

    Research output: Contribution to journalArticlepeer-review

    244 Scopus citations
  • 2006

    Complex loci in human and mouse genomes

    Engström, P. G., Suzuki, H., Ninomiya, N., Akalin, A., Sessa, L., Lavorgna, G., Brozzi, A., Luzi, L., Sin, L. T., Yang, L., Kunarso, G., Ng, E. L. C., Batalov, S., Wahlestedt, C., Kai, C., Kawai, J., Carninci, P., Hayashizaki, Y., Wells, C. & Bajic, V. B. & 4 others, Orlando, V., Reid, J. F., Lenhard, B. & Lipovich, L., Apr 2006, In: PLOS Genetics. 2, 4, p. 564-577 14 p., e47.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    265 Scopus citations
  • Genome-wide analysis of mammalian promoter architecture and evolution

    Carninci, P., Sandelin, A., Lenhard, B., Katayama, S., Shimokawa, K., Ponjavic, J., Semple, C. A. M., Taylor, M. S., Engström, P. G., Frith, M. C., Forrest, A. R. R., Alkema, W. B., Tan, S. L., Plessy, C., Kodzius, R., Ravasi, T., Kasukawa, T., Fukuda, S., Kanamori-Katayama, M. & Kitazume, Y. & 21 others, Kawaji, H., Kai, C., Nakamura, M., Konno, H., Nakano, K., Mottagui-Tabar, S., Arner, P., Chesi, A., Gustincich, S., Persichetti, F., Suzuki, H., Grimmond, S. M., Wells, C. A., Orlando, V., Wahlestedt, C., Liu, E. T., Harbers, M., Kawai, J., Bajic, V. B., Hume, D. A. & Hayashizaki, Y., Jun 2006, In: Nature Genetics. 38, 6, p. 626-635 10 p.

    Research output: Contribution to journalArticlepeer-review

    1074 Scopus citations
  • 2005

    Molecular biology: The transcriptional landscape of the mammalian genome

    Carninci, P., Kasukawa, T., Katayama, S., Gough, J., Frith, M. C., Maeda, N., Oyama, R., Ravasi, T., Lenhard, B., Wells, C., Kodzius, R., Shimokawa, K., Bajic, V. B., Brenner, S. E., Batalov, S., Forrest, A. R. R., Zavolan, M., Davis, M. J., Wilming, L. G. & Aidinis, V. & 174 others, Allen, J. E., Ambesi-Impiombato, A., Apweiler, R., Aturaliya, R. N., Bailey, T. L., Bansal, M., Baxter, L., Beisel, K. W., Bersano, T., Bono, H., Chalk, A. M., Chiu, K. P., Choudhary, V., Christoffels, A., Clutterbuck, D. R., Crowe, M. L., Dalla, E., Dalrymple, B. P., Bono, B., Gatta, G. D., Bernardo, D. D., Down, T., Engstrom, P., Fagiolini, M., Faulkner, G., Fletcher, C. F., Fukushima, T., Furuno, M., Futaki, S., Gariboldi, M., Georgii-Hemming, P., Gingeras, T. R., Gojobori, T., Green, R. E., Gustincich, S., Harbers, M., Hayashi, Y., Hensch, T. K., Hirokawa, N., Hill, D., Huminiecki, L., Iacono, M., Ikeo, K., Iwama, A., Ishikawa, T., Jakt, M., Kanapin, A., Katoh, M., Kawasawa, Y., Kelso, J., Kitamura, H., Kitano, H., Kollias, G., Krishnan, S. P. T., Kruger, A., Kummerfeld, S. K., Kurochkin, I. V., Lareau, L. F., Lazarevic, D., Lipovich, L., Liu, J., Liuni, S., McWilliam, S., Babu, M. M., Madera, M., Marchionni, L., Matsuda, H., Matsuzawa, S., Miki, H., Mignone, F., Miyake, S., Morris, K., Mottagui-Tabar, S., Mulder, N., Nakano, N., Nakauchi, H., Ng, P., Nilsson, R., Nishiguchi, S., Nishikawa, S., Nori, F., Ohara, O., Okazaki, Y., Orlando, V., Pang, K. C., Pavan, W. J., Pavesi, G., Pesole, G., Petrovsky, N., Piazza, S., Reed, J., Reid, J. F., Ring, B. Z., Ringwald, M., Rost, B., Ruan, Y., Salzberg, S. L., Sandelin, A., Schneider, C., Schönbach, C., Sekiguchi, K., Semple, C. A. M., Seno, S., Sessa, L., Sheng, Y., Shibata, Y., Shimada, H., Shimada, K., Silva, D., Sinclair, B., Sperling, S., Stupka, E., Sugiura, K., Sultana, R., Takenaka, Y., Taki, K., Tammoja, K., Tan, S. L., Tang, S., Taylor, M. S., Tegner, J., Teichmann, S. A., Ueda, H. R., Nimwegen, E., Verardo, R., Wei, C. L., Yagi, K., Yamanishi, H., Zabarovsky, E., Zhu, S., Zimmer, A., Hide, W., Bult, C., Grimmond, S. M., Teasdale, R. D., Liu, E. T., Brusic, V., Quackenbush, J., Wahlestedt, C., Mattick, J. S., Hume, D. A., Kai, C., Sasaki, D., Tomaru, Y., Fukuda, S., Kanamori-Katayama, M., Suzuki, M., Aoki, J., Arakawa, T., Iida, J., Imamura, K., Itoh, M., Kato, T., Kawaji, H., Kawagashira, N., Kawashima, T., Kojima, M., Kondo, S., Konno, H., Nakano, K., Ninomiya, N., Nishio, T., Okada, M., Plessy, C., Shibata, K., Shiraki, T., Suzuki, S., Tagami, M., Waki, K., Watahiki, A., Okamura-Oho, Y., Suzuki, H., Kawai, J. & Hayashizaki, Y., Sep 2 2005, In: SCIENCE. 309, 5740, p. 1559-1563 5 p.

    Research output: Contribution to journalArticlepeer-review

    2977 Scopus citations
  • The M/SAR elements of the bithorax complex in Drosophila melanogaster

    Boykova, T. V., Orlando, V., Lupo, R. & Bogachev, S. S., Nov 2005, In: Russian Journal of Genetics. 41, 11, p. 1206-1216 11 p.

    Research output: Contribution to journalArticlepeer-review

  • The M/SAR elements of the bithorax complex in Drosophila melanogaster

    Boykova, T. V., Orlando, V., Lpo, R. & Bogachev, S. S., 2005, In: Genetika. 41, 11, p. 1467-1479 13 p.

    Research output: Contribution to journalArticlepeer-review

  • 2004

    Epigenome changes in active and inactive Polycomb-group-controlled regions

    Breiling, A., O'Neill, L. P., D'Eliseo, D., Turner, B. M. & Orlando, V., Oct 2004, In: EMBO reports. 5, 10, p. 976-982 7 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    44 Scopus citations
  • 2002

    Wild chromatin: Regulation of eukaryotic genes in their natural chromatin context

    Orlando, V. & Jone, K. A., Aug 15 2002, In: Genes and Development. 16, 16, p. 2039-2044 6 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    12 Scopus citations
  • 2001

    Drosophila chromosome condensation proteins Topoisomerase II and Barren colocalize with Polycomb and maintain Fab-7 PRE silencing

    Lupo, R., Breiling, A., Bianchi, M. E. & Orlando, V., 2001, In: Molecular cell. 7, 1, p. 127-136 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    104 Scopus citations
  • The maternal effect gene, abnormal oocyte (abo), of Drosophila melanogaster encodes a specific negative regulator of histones

    Berloco, M., Fanti, L., Breiling, A., Orlando, V. & Pimpinelli, S., Oct 9 2001, In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 98, 21, p. 12126-12131 6 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    43 Scopus citations
  • 1998

    Binding of Trithorax and Polycomb proteins to the bithorax complex: Dynamic changes during early Drosophila embryogenesis

    Orlando, V., Jane, E. P., Chinwalla, V., Harte, P. J. & Paro, R., Sep 1 1998, In: EMBO JOURNAL. 17, 17, p. 5141-5150 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    162 Scopus citations