TY - JOUR
T1 - β-Cyclocitral is a conserved root growth regulator
AU - Dickinson, Alexandra J
AU - Lehner, Kevin
AU - Mi, Jianing
AU - Jia, Kunpeng
AU - Mijar, Medhavinee
AU - Dinneny, José
AU - Al-Babili, Salim
AU - Benfey, Philip N
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We thank Jingyuan Zhang for technical support provided for the duration of this project; Michel Havaux, Stefano D’Alessandro, Polly Hsu, and Larry Wu for helpful discussions; Dolf Weijers, Cara Winter, Colleen Drapek, and Isaiah Taylor for critical reading; and Linxing Yao (Proteomics and Metabolomics Facility, Colorado State University) for experimental assistance. This work was supported by the Arnold and Mabel Beckman Postdoctoral Fellowship (to A.J.D.); by the Howard Hughes Medical Institute and the Gordon and Betty Moore Foundation Grant GBMF3405 (to P.N.B.); and by baseline funding and Competitive Research Grant CRG4 (to S.A.-B.) from King Abdullah University of Science and Technology.
PY - 2019/5/8
Y1 - 2019/5/8
N2 - Natural compounds capable of increasing root depth and branching are desirable tools for enhancing stress tolerance in crops. We devised a sensitized screen to identify natural metabolites capable of regulating root traits in Arabidopsis β-Cyclocitral, an endogenous root compound, was found to promote cell divisions in root meristems and stimulate lateral root branching. β-Cyclocitral rescued meristematic cell divisions in ccd1ccd4 biosynthesis mutants, and β-cyclocitral-driven root growth was found to be independent of auxin, brassinosteroid, and reactive oxygen species signaling pathways. β-Cyclocitral had a conserved effect on root growth in tomato and rice and generated significantly more compact crown root systems in rice. Moreover, β-cyclocitral treatment enhanced plant vigor in rice plants exposed to salt-contaminated soil. These results indicate that β-cyclocitral is a broadly effective root growth promoter in both monocots and eudicots and could be a valuable tool to enhance crop vigor under environmental stress.
AB - Natural compounds capable of increasing root depth and branching are desirable tools for enhancing stress tolerance in crops. We devised a sensitized screen to identify natural metabolites capable of regulating root traits in Arabidopsis β-Cyclocitral, an endogenous root compound, was found to promote cell divisions in root meristems and stimulate lateral root branching. β-Cyclocitral rescued meristematic cell divisions in ccd1ccd4 biosynthesis mutants, and β-cyclocitral-driven root growth was found to be independent of auxin, brassinosteroid, and reactive oxygen species signaling pathways. β-Cyclocitral had a conserved effect on root growth in tomato and rice and generated significantly more compact crown root systems in rice. Moreover, β-cyclocitral treatment enhanced plant vigor in rice plants exposed to salt-contaminated soil. These results indicate that β-cyclocitral is a broadly effective root growth promoter in both monocots and eudicots and could be a valuable tool to enhance crop vigor under environmental stress.
UR - http://hdl.handle.net/10754/652858
UR - https://www.pnas.org/content/early/2019/05/07/1821445116
UR - http://www.scopus.com/inward/record.url?scp=85066100763&partnerID=8YFLogxK
U2 - 10.1073/pnas.1821445116
DO - 10.1073/pnas.1821445116
M3 - Article
C2 - 31068462
SN - 0027-8424
VL - 116
SP - 10563
EP - 10567
JO - Proceedings of the National Academy of Sciences
JF - Proceedings of the National Academy of Sciences
IS - 21
ER -