3D-Printed Cross-Flow Mixer Gradient within Minutes for Microfluidic Applications

Shilpa Sivashankar; Hend Mkaouar; Yousof Mashraei; Kholod Alamoudi; Niveen M. Khashab; Khaled N. Salama

doi:10.1109/biocas.2018.8584743

3D-Printed Cross-Flow Mixer Gradient within Minutes for Microfluidic Applications

Shilpa Sivashankar, Hend Mkaouar, Yousof Mashraei, Kholod Alamoudi, Niveen M. Khashab, Khaled N. Salama

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

This paper reports on a compact new cross-flow 3D mixer that is integrated with a gradient generator into one device for toxicology applications. The device has two parts: the first mixes two solvents while the second generates gradients of the obtained solutions. The outlet of the 3D cross-flow mixer is integrated with a linear channel that aids in achieving this gradient by changing flow rates. The dye-visualization test confirm the functionality of mixer and gradient. The mesh structure of the mixer provided excellent mixing regime and is confirmed by experimental and simulation results. The compact size (25 Ã— 25 Ã— 3 mm) and the reduced cost ($1.5) of the device enable the device to be disposable. We aim to study doxorubicin drug at different concentration generated by the device to culture human embryonic kidney (HEK) from the 293-cell line enabling the devices to be used for cellular studies. The carefully designed geometry of the device finds applications in drug toxicology testing devices, micro-total analysis systems ( µ- TAs),and other lab-on-chip devices.

Original language	English (US)
Title of host publication	2018 IEEE Biomedical Circuits and Systems Conference (BioCAS)
Publisher	Institute of Electrical and Electronics Engineers (IEEE)
ISBN (Print)	9781538636039
DOIs	https://doi.org/10.1109/biocas.2018.8584743
State	Published - Dec 24 2018

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10.1109/biocas.2018.8584743

https://repository.kaust.edu.sa/bitstream/10754/630892/1/BIOCAS%202018_final.pdf

Cite this

@inproceedings{aadf73a62db644778d9a0e7eff16277c,

title = "3D-Printed Cross-Flow Mixer Gradient within Minutes for Microfluidic Applications",

abstract = "This paper reports on a compact new cross-flow 3D mixer that is integrated with a gradient generator into one device for toxicology applications. The device has two parts: the first mixes two solvents while the second generates gradients of the obtained solutions. The outlet of the 3D cross-flow mixer is integrated with a linear channel that aids in achieving this gradient by changing flow rates. The dye-visualization test confirm the functionality of mixer and gradient. The mesh structure of the mixer provided excellent mixing regime and is confirmed by experimental and simulation results. The compact size (25 {\~A}— 25 {\~A}— 3 mm) and the reduced cost ($1.5) of the device enable the device to be disposable. We aim to study doxorubicin drug at different concentration generated by the device to culture human embryonic kidney (HEK) from the 293-cell line enabling the devices to be used for cellular studies. The carefully designed geometry of the device finds applications in drug toxicology testing devices, micro-total analysis systems ( µ- TAs),and other lab-on-chip devices.",

author = "Shilpa Sivashankar and Hend Mkaouar and Yousof Mashraei and Kholod Alamoudi and Khashab, {Niveen M.} and Salama, {Khaled N.}",

note = "KAUST Repository Item: Exported on 2020-10-01",

year = "2018",

month = dec,

day = "24",

doi = "10.1109/biocas.2018.8584743",

language = "English (US)",

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T1 - 3D-Printed Cross-Flow Mixer Gradient within Minutes for Microfluidic Applications

AU - Sivashankar, Shilpa

AU - Mkaouar, Hend

AU - Mashraei, Yousof

AU - Alamoudi, Kholod

AU - Khashab, Niveen M.

AU - Salama, Khaled N.

N1 - KAUST Repository Item: Exported on 2020-10-01

PY - 2018/12/24

Y1 - 2018/12/24

N2 - This paper reports on a compact new cross-flow 3D mixer that is integrated with a gradient generator into one device for toxicology applications. The device has two parts: the first mixes two solvents while the second generates gradients of the obtained solutions. The outlet of the 3D cross-flow mixer is integrated with a linear channel that aids in achieving this gradient by changing flow rates. The dye-visualization test confirm the functionality of mixer and gradient. The mesh structure of the mixer provided excellent mixing regime and is confirmed by experimental and simulation results. The compact size (25 Ã— 25 Ã— 3 mm) and the reduced cost ($1.5) of the device enable the device to be disposable. We aim to study doxorubicin drug at different concentration generated by the device to culture human embryonic kidney (HEK) from the 293-cell line enabling the devices to be used for cellular studies. The carefully designed geometry of the device finds applications in drug toxicology testing devices, micro-total analysis systems ( µ- TAs),and other lab-on-chip devices.

AB - This paper reports on a compact new cross-flow 3D mixer that is integrated with a gradient generator into one device for toxicology applications. The device has two parts: the first mixes two solvents while the second generates gradients of the obtained solutions. The outlet of the 3D cross-flow mixer is integrated with a linear channel that aids in achieving this gradient by changing flow rates. The dye-visualization test confirm the functionality of mixer and gradient. The mesh structure of the mixer provided excellent mixing regime and is confirmed by experimental and simulation results. The compact size (25 Ã— 25 Ã— 3 mm) and the reduced cost ($1.5) of the device enable the device to be disposable. We aim to study doxorubicin drug at different concentration generated by the device to culture human embryonic kidney (HEK) from the 293-cell line enabling the devices to be used for cellular studies. The carefully designed geometry of the device finds applications in drug toxicology testing devices, micro-total analysis systems ( µ- TAs),and other lab-on-chip devices.

UR - http://hdl.handle.net/10754/630892

UR - https://ieeexplore.ieee.org/document/8584743

UR - http://www.scopus.com/inward/record.url?scp=85060881826&partnerID=8YFLogxK

U2 - 10.1109/biocas.2018.8584743

DO - 10.1109/biocas.2018.8584743

M3 - Conference contribution

SN - 9781538636039

BT - 2018 IEEE Biomedical Circuits and Systems Conference (BioCAS)

PB - Institute of Electrical and Electronics Engineers (IEEE)

ER -

3D-Printed Cross-Flow Mixer Gradient within Minutes for Microfluidic Applications

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