A compact and disposable transdermal drug delivery system

M. Matteucci; M. Casella; M. Bedoni; E. Donetti; M. Fanetti; F. De Angelis; F. Gramatica; E. Di Fabrizio

doi:10.1016/j.mee.2007.12.067

A compact and disposable transdermal drug delivery system

M. Matteucci^*, M. Casella, M. Bedoni, E. Donetti, M. Fanetti, F. De Angelis, F. Gramatica, E. Di Fabrizio

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

This work presents a portable transdermal drug delivery system that combines a magnetically actuated micro gear pump with a microneedle array. Micropart fabrication is performed through DXRL and LIGA techniques. The manufacturing process of both micropump and microneedle array are described together with wear issues. Results show that the assembled device can deliver rates that go from 0.1 to 1.2 ml/min at gear speed ranging from 1000 to 8500 rpm. First skin piercing experiments are also described.

Original language	English (US)
Pages (from-to)	1066-1073
Number of pages	8
Journal	Microelectronic Engineering
Volume	85
Issue number	5-6
DOIs	https://doi.org/10.1016/j.mee.2007.12.067
State	Published - May 2008
Externally published	Yes

Keywords

Deep X-ray lithography
LIGA
Soft lithography
Transdermal drug delivery

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Condensed Matter Physics
Surfaces, Coatings and Films
Electrical and Electronic Engineering

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10.1016/j.mee.2007.12.067

Cite this

@article{4fa442bb77cc4031ae058dc200cc21eb,

title = "A compact and disposable transdermal drug delivery system",

abstract = "This work presents a portable transdermal drug delivery system that combines a magnetically actuated micro gear pump with a microneedle array. Micropart fabrication is performed through DXRL and LIGA techniques. The manufacturing process of both micropump and microneedle array are described together with wear issues. Results show that the assembled device can deliver rates that go from 0.1 to 1.2 ml/min at gear speed ranging from 1000 to 8500 rpm. First skin piercing experiments are also described.",

keywords = "Deep X-ray lithography, LIGA, Soft lithography, Transdermal drug delivery",

author = "M. Matteucci and M. Casella and M. Bedoni and E. Donetti and M. Fanetti and {De Angelis}, F. and F. Gramatica and {Di Fabrizio}, E.",

year = "2008",

month = may,

doi = "10.1016/j.mee.2007.12.067",

language = "English (US)",

volume = "85",

pages = "1066--1073",

journal = "Microelectronic Engineering",

issn = "0167-9317",

publisher = "ELSEVIER SCIENCE BV",

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TY - JOUR

T1 - A compact and disposable transdermal drug delivery system

AU - Matteucci, M.

AU - Casella, M.

AU - Bedoni, M.

AU - Donetti, E.

AU - Fanetti, M.

AU - De Angelis, F.

AU - Gramatica, F.

AU - Di Fabrizio, E.

PY - 2008/5

Y1 - 2008/5

N2 - This work presents a portable transdermal drug delivery system that combines a magnetically actuated micro gear pump with a microneedle array. Micropart fabrication is performed through DXRL and LIGA techniques. The manufacturing process of both micropump and microneedle array are described together with wear issues. Results show that the assembled device can deliver rates that go from 0.1 to 1.2 ml/min at gear speed ranging from 1000 to 8500 rpm. First skin piercing experiments are also described.

AB - This work presents a portable transdermal drug delivery system that combines a magnetically actuated micro gear pump with a microneedle array. Micropart fabrication is performed through DXRL and LIGA techniques. The manufacturing process of both micropump and microneedle array are described together with wear issues. Results show that the assembled device can deliver rates that go from 0.1 to 1.2 ml/min at gear speed ranging from 1000 to 8500 rpm. First skin piercing experiments are also described.

KW - Deep X-ray lithography

KW - LIGA

KW - Soft lithography

KW - Transdermal drug delivery

UR - http://www.scopus.com/inward/record.url?scp=44149122197&partnerID=8YFLogxK

U2 - 10.1016/j.mee.2007.12.067

DO - 10.1016/j.mee.2007.12.067

M3 - Article

AN - SCOPUS:44149122197

SN - 0167-9317

VL - 85

SP - 1066

EP - 1073

JO - Microelectronic Engineering

JF - Microelectronic Engineering

IS - 5-6

ER -

A compact and disposable transdermal drug delivery system

Abstract

Keywords

ASJC Scopus subject areas

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