TY - JOUR
T1 - A constitutive model of soft tissue: From nanoscale collagen to tissue continuum
AU - Tang, Huang
AU - Buehler, Markus J.
AU - Moran, Brian
N1 - KAUST Repository Item: Exported on 2020-10-01
PY - 2009/4/8
Y1 - 2009/4/8
N2 - Soft collagenous tissue features many hierarchies of structure, starting from tropocollagen molecules that form fibrils, and proceeding to a bundle of fibrils that form fibers. Here we report the development of an atomistically informed continuum model of collagenous tissue. Results from full atomistic and molecular modeling are linked with a continuum theory of a fiber-reinforced composite, handshaking the fibril scale to the fiber and continuum scale in a hierarchical multi-scale simulation approach. Our model enables us to study the continuum-level response of the tissue as a function of cross-link density, making a link between nanoscale collagen features and material properties at larger tissue scales. The results illustrate a strong dependence of the continuum response as a function of nanoscopic structural features, providing evidence for the notion that the molecular basis for protein materials is important in defining their larger-scale mechanical properties. © 2009 Biomedical Engineering Society.
AB - Soft collagenous tissue features many hierarchies of structure, starting from tropocollagen molecules that form fibrils, and proceeding to a bundle of fibrils that form fibers. Here we report the development of an atomistically informed continuum model of collagenous tissue. Results from full atomistic and molecular modeling are linked with a continuum theory of a fiber-reinforced composite, handshaking the fibril scale to the fiber and continuum scale in a hierarchical multi-scale simulation approach. Our model enables us to study the continuum-level response of the tissue as a function of cross-link density, making a link between nanoscale collagen features and material properties at larger tissue scales. The results illustrate a strong dependence of the continuum response as a function of nanoscopic structural features, providing evidence for the notion that the molecular basis for protein materials is important in defining their larger-scale mechanical properties. © 2009 Biomedical Engineering Society.
UR - http://hdl.handle.net/10754/561415
UR - http://link.springer.com/10.1007/s10439-009-9679-0
UR - http://www.scopus.com/inward/record.url?scp=67349234865&partnerID=8YFLogxK
U2 - 10.1007/s10439-009-9679-0
DO - 10.1007/s10439-009-9679-0
M3 - Article
SN - 0090-6964
VL - 37
SP - 1117
EP - 1130
JO - Annals of Biomedical Engineering
JF - Annals of Biomedical Engineering
IS - 6
ER -