A database of immunoglobulins with integrated tools: DIGIT.

Anna Chailyan; Anna Tramontano; Paolo Marcatili

doi:10.1093/nar/gkr806

A database of immunoglobulins with integrated tools: DIGIT.

Anna Chailyan, Anna Tramontano, Paolo Marcatili

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The DIGIT (Database of ImmunoGlobulins with Integrated Tools) database (http://biocomputing.it/digit) is an integrated resource storing sequences of annotated immunoglobulin variable domains and enriched with tools for searching and analyzing them. The annotations in the database include information on the type of antigen, the respective germline sequences and on pairing information between light and heavy chains. Other annotations, such as the identification of the complementarity determining regions, assignment of their structural class and identification of mutations with respect to the germline, are computed on the fly and can also be obtained for user-submitted sequences. The system allows customized BLAST searches and automatic building of 3D models of the domains to be performed.

Original language	English (US)
Pages (from-to)	D1230-D1234
Number of pages	1
Journal	Nucleic Acids Research
Volume	40
Issue number	D1
DOIs	https://doi.org/10.1093/nar/gkr806
State	Published - Nov 10 2011
Externally published	Yes

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10.1093/nar/gkr806

https://repository.kaust.edu.sa/bitstream/10754/596755/1/PMC3245095.pdf

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title = "A database of immunoglobulins with integrated tools: DIGIT.",

abstract = "The DIGIT (Database of ImmunoGlobulins with Integrated Tools) database (http://biocomputing.it/digit) is an integrated resource storing sequences of annotated immunoglobulin variable domains and enriched with tools for searching and analyzing them. The annotations in the database include information on the type of antigen, the respective germline sequences and on pairing information between light and heavy chains. Other annotations, such as the identification of the complementarity determining regions, assignment of their structural class and identification of mutations with respect to the germline, are computed on the fly and can also be obtained for user-submitted sequences. The system allows customized BLAST searches and automatic building of 3D models of the domains to be performed.",

author = "Anna Chailyan and Anna Tramontano and Paolo Marcatili",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): KUK-I1-012-43 Acknowledgements: King Abdullah University of Science and Technology (KAUST) (Award number KUK-I1-012-43); FIRB Proteomica, Ministery of Health grant (Contract No. Onc_Ord 25/07); IIT SEED project. Funding for open access charge: King Abdullah University of Science and Technology (KAUST) (Award number KUK-I1-012-43). This publication acknowledges KAUST support, but has no KAUST affiliated authors.",

year = "2011",

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doi = "10.1093/nar/gkr806",

language = "English (US)",

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AU - Marcatili, Paolo

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A database of immunoglobulins with integrated tools: DIGIT.

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