TY - GEN
T1 - A magnetic particle micro-trap for large trapping surfaces
AU - Gooneratne, Chinthaka Pasan
AU - Liang, Cai
AU - Giouroudi, Ioanna
AU - Kosel, Jürgen
N1 - KAUST Repository Item: Exported on 2020-10-01
PY - 2012/1/9
Y1 - 2012/1/9
N2 - Manipulation of micron-size magnetic particles of the superparamagnetic type contributes significantly in many applications like controlling the antibody/antigen binding process in immunoassays. Specifically, more target biomolecules can be attached/tagged and analyzed since the three dimensional structure of the magnetic particles increases the surface to volume ratio. Additionally, such biomolecular-tagged magnetic particles can be easily manipulated by an external magnetic field due to their superparamagnetic behavior. Therefore, magnetic particle- based immunoassays are extensively applied in micro-flow cytometry. The design of a square-loop micro-trap as a magnetic particle manipulator as well as numerical and experimental analysis is presented. Experimental results showed that the micro-trap could successfully trap and concentrate magnetic particles from a large to a small area with a high spatial range.
AB - Manipulation of micron-size magnetic particles of the superparamagnetic type contributes significantly in many applications like controlling the antibody/antigen binding process in immunoassays. Specifically, more target biomolecules can be attached/tagged and analyzed since the three dimensional structure of the magnetic particles increases the surface to volume ratio. Additionally, such biomolecular-tagged magnetic particles can be easily manipulated by an external magnetic field due to their superparamagnetic behavior. Therefore, magnetic particle- based immunoassays are extensively applied in micro-flow cytometry. The design of a square-loop micro-trap as a magnetic particle manipulator as well as numerical and experimental analysis is presented. Experimental results showed that the micro-trap could successfully trap and concentrate magnetic particles from a large to a small area with a high spatial range.
UR - http://hdl.handle.net/10754/552531
UR - http://linkinghub.elsevier.com/retrieve/pii/S1877705811059650
UR - http://www.scopus.com/inward/record.url?scp=84857163011&partnerID=8YFLogxK
U2 - 10.1016/j.proeng.2011.12.296
DO - 10.1016/j.proeng.2011.12.296
M3 - Conference contribution
SP - 1201
EP - 1204
BT - Procedia Engineering
PB - Elsevier BV
ER -