A powerful reagent for synthesis of weinreb amides directly from carboxylic acids

Teng Niu; Weiming Zhang; Danfeng Huang; Changming Xu; Haifeng Wang; Yulai Hu

doi:10.1021/ol901886u

A powerful reagent for synthesis of weinreb amides directly from carboxylic acids

Teng Niu, Weiming Zhang, Danfeng Huang^*, Changming Xu, Haifeng Wang, Yulai Hu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

A powerful reagent, P[NCH₃(OCH₃)]₃ (3), for conversion of carboxylic acids directly to Weinreb amides was developed. In most cases the yields of the corresponding Weinreb amides were above 90% when P[NCH₃(OCH₃)]₃ was heated with aromatic and aliphatic carboxyllc acids in toluene. The sterically hindered carboxyllc acids can also give the corresponding Welnreb amides In excellent yields.

Original language	English (US)
Pages (from-to)	4474-4477
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	19
DOIs	https://doi.org/10.1021/ol901886u
State	Published - Oct 1 2009
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "A powerful reagent, P[NCH3(OCH3)]3 (3), for conversion of carboxylic acids directly to Weinreb amides was developed. In most cases the yields of the corresponding Weinreb amides were above 90% when P[NCH3(OCH3)]3 was heated with aromatic and aliphatic carboxyllc acids in toluene. The sterically hindered carboxyllc acids can also give the corresponding Welnreb amides In excellent yields.",

author = "Teng Niu and Weiming Zhang and Danfeng Huang and Changming Xu and Haifeng Wang and Yulai Hu",

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T1 - A powerful reagent for synthesis of weinreb amides directly from carboxylic acids

AU - Niu, Teng

AU - Zhang, Weiming

AU - Huang, Danfeng

AU - Xu, Changming

AU - Wang, Haifeng

AU - Hu, Yulai

PY - 2009/10/1

Y1 - 2009/10/1

N2 - A powerful reagent, P[NCH3(OCH3)]3 (3), for conversion of carboxylic acids directly to Weinreb amides was developed. In most cases the yields of the corresponding Weinreb amides were above 90% when P[NCH3(OCH3)]3 was heated with aromatic and aliphatic carboxyllc acids in toluene. The sterically hindered carboxyllc acids can also give the corresponding Welnreb amides In excellent yields.

AB - A powerful reagent, P[NCH3(OCH3)]3 (3), for conversion of carboxylic acids directly to Weinreb amides was developed. In most cases the yields of the corresponding Weinreb amides were above 90% when P[NCH3(OCH3)]3 was heated with aromatic and aliphatic carboxyllc acids in toluene. The sterically hindered carboxyllc acids can also give the corresponding Welnreb amides In excellent yields.

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DO - 10.1021/ol901886u

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JO - Organic Letters

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ER -

A powerful reagent for synthesis of weinreb amides directly from carboxylic acids

Abstract

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