A protocol for the gram-scale synthesis of polyfluoroaryl sulfides via an SNAr step

Cheng Lin Chan, Shao-Chi Lee, Hsuan Hung Liao

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Polyfluoroaryl sulfide is one of the prevalent motifs ubiquitous in materials and pharmaceutical chemistry. We herein describe a simple yet efficient procedure for their synthesis from readily available thiols and polyfluoroarenes via an SNAr step. We detail specific steps for a gram-scale preparation of 2-((perfluoropyridin-4-yl)thio)benzo[d]thiazole 3 from mercaptobenzothiazole 1 and pentafluoropyridine 2.
Original languageEnglish (US)
Pages (from-to)102043
JournalSTAR Protocols
Volume4
Issue number1
DOIs
StatePublished - Jan 19 2023

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