A putative ABC transporter confers durable resistance to multiple fungal pathogens in wheat

Simon G. Krattinger; Evans S. Lagudah; Wolfgang Spielmeyer; Ravi P. Singh; Julio Huerta-Espino; Helen McFadden; Eligio Bossolini; Liselotte L. Selter; Beat Keller

doi:10.1126/science.1166453

A putative ABC transporter confers durable resistance to multiple fungal pathogens in wheat

Simon G. Krattinger, Evans S. Lagudah, Wolfgang Spielmeyer, Ravi P. Singh, Julio Huerta-Espino, Helen McFadden, Eligio Bossolini, Liselotte L. Selter, Beat Keller

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1034 Scopus citations

Abstract

Agricultural crops benefit from resistance to pathogens that endures over years and generations of both pest and crop. Durable disease resistance, which may be partial or complete, can be controlled by several genes. Some of the most devastating fungal pathogens in wheat are leaf rust, stripe rust, and powdery mildew. The wheat gene Lr34 has supported resistance to these pathogens for more than 50 years. Lr34 is now shared by wheat cultivars around the world. Here, we show that the LR34 protein resembles adenosine triphosphate-binding cassette transporters of the pleiotropic drug resistance subfamily. Alleles of Lr34 conferring resistance or susceptibility differ by three genetic polymorphisms. The Lr34 gene, which functions in the adult plant, stimulates senescence-like processes in the flag leaf tips and edges.

Original language	English (US)
Pages (from-to)	1360-1363
Number of pages	4
Journal	SCIENCE
Volume	323
Issue number	5919
DOIs	https://doi.org/10.1126/science.1166453
State	Published - 2009
Externally published	Yes

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title = "A putative ABC transporter confers durable resistance to multiple fungal pathogens in wheat",

abstract = "Agricultural crops benefit from resistance to pathogens that endures over years and generations of both pest and crop. Durable disease resistance, which may be partial or complete, can be controlled by several genes. Some of the most devastating fungal pathogens in wheat are leaf rust, stripe rust, and powdery mildew. The wheat gene Lr34 has supported resistance to these pathogens for more than 50 years. Lr34 is now shared by wheat cultivars around the world. Here, we show that the LR34 protein resembles adenosine triphosphate-binding cassette transporters of the pleiotropic drug resistance subfamily. Alleles of Lr34 conferring resistance or susceptibility differ by three genetic polymorphisms. The Lr34 gene, which functions in the adult plant, stimulates senescence-like processes in the flag leaf tips and edges.",

author = "Krattinger, {Simon G.} and Lagudah, {Evans S.} and Wolfgang Spielmeyer and Singh, {Ravi P.} and Julio Huerta-Espino and Helen McFadden and Eligio Bossolini and Selter, {Liselotte L.} and Beat Keller",

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T1 - A putative ABC transporter confers durable resistance to multiple fungal pathogens in wheat

AU - Krattinger, Simon G.

AU - Lagudah, Evans S.

AU - Spielmeyer, Wolfgang

AU - Singh, Ravi P.

AU - Huerta-Espino, Julio

AU - McFadden, Helen

AU - Bossolini, Eligio

AU - Selter, Liselotte L.

AU - Keller, Beat

PY - 2009

Y1 - 2009

N2 - Agricultural crops benefit from resistance to pathogens that endures over years and generations of both pest and crop. Durable disease resistance, which may be partial or complete, can be controlled by several genes. Some of the most devastating fungal pathogens in wheat are leaf rust, stripe rust, and powdery mildew. The wheat gene Lr34 has supported resistance to these pathogens for more than 50 years. Lr34 is now shared by wheat cultivars around the world. Here, we show that the LR34 protein resembles adenosine triphosphate-binding cassette transporters of the pleiotropic drug resistance subfamily. Alleles of Lr34 conferring resistance or susceptibility differ by three genetic polymorphisms. The Lr34 gene, which functions in the adult plant, stimulates senescence-like processes in the flag leaf tips and edges.

AB - Agricultural crops benefit from resistance to pathogens that endures over years and generations of both pest and crop. Durable disease resistance, which may be partial or complete, can be controlled by several genes. Some of the most devastating fungal pathogens in wheat are leaf rust, stripe rust, and powdery mildew. The wheat gene Lr34 has supported resistance to these pathogens for more than 50 years. Lr34 is now shared by wheat cultivars around the world. Here, we show that the LR34 protein resembles adenosine triphosphate-binding cassette transporters of the pleiotropic drug resistance subfamily. Alleles of Lr34 conferring resistance or susceptibility differ by three genetic polymorphisms. The Lr34 gene, which functions in the adult plant, stimulates senescence-like processes in the flag leaf tips and edges.

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A putative ABC transporter confers durable resistance to multiple fungal pathogens in wheat

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