TY - JOUR

T1 - A review of matrix sir arino epidemic models

AU - Avram, Florin

AU - Adenane, Rim

AU - Ketcheson, David I.

N1 - KAUST Repository Item: Exported on 2021-08-10
Acknowledgements: We thank the two referees for their thorough reviews and suggestions.

PY - 2021/6/28

Y1 - 2021/6/28

N2 - Many of the models used nowadays in mathematical epidemiology, in particular in COVID-19 research, belong to a certain subclass of compartmental models whose classes may be divided into three “(x, y, z)” groups, which we will call respectively “susceptible/entrance, diseased, and output” (in the classic SIR case, there is only one class of each type). Roughly, the ODE dynamics of these models contains only linear terms, with the exception of products between x and y terms. It has long been noticed that the reproduction number R has a very simple Formula in terms of the matrices which define the model, and an explicit first integral Formula is also available. These results can be traced back at least to Arino, Brauer, van den Driessche, Watmough, and Wu (2007) and to Feng (2007), respectively, and may be viewed as the “basic laws of SIR-type epidemics”. However, many papers continue to reprove them in particular instances. This motivated us to redraw attention to these basic laws and provide a self-contained reference of related formulas for (x, y, z) models. For the case of one susceptible class, we propose to use the name SIR-PH, due to a simple probabilistic interpretation as SIR models where the exponential infection time has been replaced by a PH-type distribution. Note that to each SIR-PH model, one may associate a scalar quantity Y(t) which satisfies “classic SIR relations”, which may be useful to obtain approximate control policies.

AB - Many of the models used nowadays in mathematical epidemiology, in particular in COVID-19 research, belong to a certain subclass of compartmental models whose classes may be divided into three “(x, y, z)” groups, which we will call respectively “susceptible/entrance, diseased, and output” (in the classic SIR case, there is only one class of each type). Roughly, the ODE dynamics of these models contains only linear terms, with the exception of products between x and y terms. It has long been noticed that the reproduction number R has a very simple Formula in terms of the matrices which define the model, and an explicit first integral Formula is also available. These results can be traced back at least to Arino, Brauer, van den Driessche, Watmough, and Wu (2007) and to Feng (2007), respectively, and may be viewed as the “basic laws of SIR-type epidemics”. However, many papers continue to reprove them in particular instances. This motivated us to redraw attention to these basic laws and provide a self-contained reference of related formulas for (x, y, z) models. For the case of one susceptible class, we propose to use the name SIR-PH, due to a simple probabilistic interpretation as SIR models where the exponential infection time has been replaced by a PH-type distribution. Note that to each SIR-PH model, one may associate a scalar quantity Y(t) which satisfies “classic SIR relations”, which may be useful to obtain approximate control policies.

UR - http://hdl.handle.net/10754/669601

UR - https://www.mdpi.com/2227-7390/9/13/1513

UR - http://www.scopus.com/inward/record.url?scp=85109419535&partnerID=8YFLogxK

U2 - 10.3390/math9131513

DO - 10.3390/math9131513

M3 - Article

SN - 2227-7390

VL - 9

SP - 1513

JO - Mathematics

JF - Mathematics

IS - 13

ER -