A Review of Spatial Causal Inference Methods for Environmental and Epidemiological Applications

Brian J. Reich, Shu Yang, Yawen Guan, Andrew B. Giffin, Matthew J. Miller, Ana Rappold

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


The scientific rigor and computational methods of causal inference have had great impacts on many disciplines but have only recently begun to take hold in spatial applications. Spatial causal inference poses analytic challenges due to complex correlation structures and interference between the treatment at one location and the outcomes at others. In this paper, we review the current literature on spatial causal inference and identify areas of future work. We first discuss methods that exploit spatial structure to account for unmeasured confounding variables. We then discuss causal analysis in the presence of spatial interference including several common assumptions used to reduce the complexity of the interference patterns under consideration. These methods are extended to the spatiotemporal case where we compare and contrast the potential outcomes framework with Granger causality and to geostatistical analyses involving spatial random fields of treatments and responses. The methods are introduced in the context of observational environmental and epidemiological studies and are compared using both a simulation study and analysis of the effect of ambient air pollution on COVID-19 mortality rate. Code to implement many of the methods using the popular Bayesian software OpenBUGS is provided.
Original languageEnglish (US)
Pages (from-to)605-634
Number of pages30
JournalInternational Statistical Review
Issue number3
StatePublished - May 31 2021
Externally publishedYes

ASJC Scopus subject areas

  • Statistics and Probability
  • Statistics, Probability and Uncertainty


Dive into the research topics of 'A Review of Spatial Causal Inference Methods for Environmental and Epidemiological Applications'. Together they form a unique fingerprint.

Cite this