A sequence homology between the pX genes of HTLV-I/II and the murine IL-3 gene

Takashi Gojobori; Shin ichi Aota; Tadashi Inoue; Kunitada Shimotohno

doi:10.1016/0014-5793(86)81023-7

A sequence homology between the pX genes of HTLV-I/II and the murine IL-3 gene

Takashi Gojobori^*, Shin ichi Aota, Tadashi Inoue, Kunitada Shimotohno

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Searching the protein sequence database for amino acid sequences homologous to the x-lor sequence in the pX region of human T-cell leukemia virus types I and II (HTLV-I/II), we found that there is a region of 38 amino acids where the murine interleukin 3 (IL-3) sequence has a 40% homology with the x-lor sequence. A statistical analysis shows that this homology is highly significant with a probability of 1.57 × 10^-10. The biological implication of this homology is discussed.

Original language	English (US)
Pages (from-to)	231-235
Number of pages	5
Journal	FEBS Letters
Volume	208
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(86)81023-7
State	Published - Nov 24 1986
Externally published	Yes

Keywords

HTLV-I HLTV-II pX gene x-lor gene Interleukin 3 Sequence homology Leukemogenesis Oncogene

ASJC Scopus subject areas

Genetics
Molecular Biology
Biophysics
Structural Biology
Biochemistry
Cell Biology

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10.1016/0014-5793(86)81023-7

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title = "A sequence homology between the pX genes of HTLV-I/II and the murine IL-3 gene",

abstract = "Searching the protein sequence database for amino acid sequences homologous to the x-lor sequence in the pX region of human T-cell leukemia virus types I and II (HTLV-I/II), we found that there is a region of 38 amino acids where the murine interleukin 3 (IL-3) sequence has a 40% homology with the x-lor sequence. A statistical analysis shows that this homology is highly significant with a probability of 1.57 × 10-10. The biological implication of this homology is discussed.",

keywords = "HTLV-I HLTV-II pX gene x-lor gene Interleukin 3 Sequence homology Leukemogenesis Oncogene",

author = "Takashi Gojobori and Aota, {Shin ichi} and Tadashi Inoue and Kunitada Shimotohno",

note = "Funding Information: was supported by a Grant-in-Aid from the Ministry of Education, Science and Culture of Japan to T.G., T.I. and K.S., and NIH grant GM-28672 and NIMH grant MH-31302 to Dr Shozo Yokoyama.",

year = "1986",

month = nov,

day = "24",

doi = "10.1016/0014-5793(86)81023-7",

language = "English (US)",

volume = "208",

pages = "231--235",

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T1 - A sequence homology between the pX genes of HTLV-I/II and the murine IL-3 gene

AU - Gojobori, Takashi

AU - Aota, Shin ichi

AU - Inoue, Tadashi

AU - Shimotohno, Kunitada

N1 - Funding Information: was supported by a Grant-in-Aid from the Ministry of Education, Science and Culture of Japan to T.G., T.I. and K.S., and NIH grant GM-28672 and NIMH grant MH-31302 to Dr Shozo Yokoyama.

PY - 1986/11/24

Y1 - 1986/11/24

N2 - Searching the protein sequence database for amino acid sequences homologous to the x-lor sequence in the pX region of human T-cell leukemia virus types I and II (HTLV-I/II), we found that there is a region of 38 amino acids where the murine interleukin 3 (IL-3) sequence has a 40% homology with the x-lor sequence. A statistical analysis shows that this homology is highly significant with a probability of 1.57 × 10-10. The biological implication of this homology is discussed.

AB - Searching the protein sequence database for amino acid sequences homologous to the x-lor sequence in the pX region of human T-cell leukemia virus types I and II (HTLV-I/II), we found that there is a region of 38 amino acids where the murine interleukin 3 (IL-3) sequence has a 40% homology with the x-lor sequence. A statistical analysis shows that this homology is highly significant with a probability of 1.57 × 10-10. The biological implication of this homology is discussed.

KW - HTLV-I HLTV-II pX gene x-lor gene Interleukin 3 Sequence homology Leukemogenesis Oncogene

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DO - 10.1016/0014-5793(86)81023-7

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A sequence homology between the pX genes of HTLV-I/II and the murine IL-3 gene

Abstract

Keywords

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