A unique trimolecular michael reaction and cyclization

Mohammad M. Al-Arab; Bader S. Ghanem; Alan O. Fitton

doi:10.1016/S0040-4020(01)89531-4

A unique trimolecular michael reaction and cyclization

Mohammad M. Al-Arab^*, Bader S. Ghanem, Alan O. Fitton

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

1,3-Diaryl-2-propene-1-ones react with ethyl cyanoacetate in presence of sodium ethoxide at room temperature to give 2-aroyl-1,3,5-triaryl-4-carbethoxy-4-cyanocyclohexanols. The structure of the reaction products was established by infrared, H-1 and C-13 nuclear magnetic resonance spectral data as well as elemental analysis. X-ray crystallography shows the presence of the cyclohexanol moeity.

Original language	English (US)
Pages (from-to)	6545-6552
Number of pages	8
Journal	Tetrahedron
Volume	45
Issue number	20
DOIs	https://doi.org/10.1016/S0040-4020(01)89531-4
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4020(01)89531-4

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@article{e27589131143426b8e530126805e8e53,

title = "A unique trimolecular michael reaction and cyclization",

abstract = "1,3-Diaryl-2-propene-1-ones react with ethyl cyanoacetate in presence of sodium ethoxide at room temperature to give 2-aroyl-1,3,5-triaryl-4-carbethoxy-4-cyanocyclohexanols. The structure of the reaction products was established by infrared, H-1 and C-13 nuclear magnetic resonance spectral data as well as elemental analysis. X-ray crystallography shows the presence of the cyclohexanol moeity.",

author = "Al-Arab, {Mohammad M.} and Ghanem, {Bader S.} and Fitton, {Alan O.}",

year = "1989",

doi = "10.1016/S0040-4020(01)89531-4",

language = "English (US)",

volume = "45",

pages = "6545--6552",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd",

number = "20",

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TY - JOUR

T1 - A unique trimolecular michael reaction and cyclization

AU - Al-Arab, Mohammad M.

AU - Ghanem, Bader S.

AU - Fitton, Alan O.

PY - 1989

Y1 - 1989

N2 - 1,3-Diaryl-2-propene-1-ones react with ethyl cyanoacetate in presence of sodium ethoxide at room temperature to give 2-aroyl-1,3,5-triaryl-4-carbethoxy-4-cyanocyclohexanols. The structure of the reaction products was established by infrared, H-1 and C-13 nuclear magnetic resonance spectral data as well as elemental analysis. X-ray crystallography shows the presence of the cyclohexanol moeity.

AB - 1,3-Diaryl-2-propene-1-ones react with ethyl cyanoacetate in presence of sodium ethoxide at room temperature to give 2-aroyl-1,3,5-triaryl-4-carbethoxy-4-cyanocyclohexanols. The structure of the reaction products was established by infrared, H-1 and C-13 nuclear magnetic resonance spectral data as well as elemental analysis. X-ray crystallography shows the presence of the cyclohexanol moeity.

UR - http://www.scopus.com/inward/record.url?scp=0001320695&partnerID=8YFLogxK

U2 - 10.1016/S0040-4020(01)89531-4

DO - 10.1016/S0040-4020(01)89531-4

M3 - Article

AN - SCOPUS:0001320695

SN - 0040-4020

VL - 45

SP - 6545

EP - 6552

JO - Tetrahedron

JF - Tetrahedron

IS - 20

ER -

A unique trimolecular michael reaction and cyclization

Abstract

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