Acetal-modified dextran microparticles with controlled degradation kinetics and surface functionality for gene delivery in phagocytic and non-phagocytic cells

Joel A. Cohen; Tristan T. Beaudette; Jessica L. Cohen; Kyle E. Broaders; Eric M. Bachelder; Jean M.J. Fréchet

doi:10.1002/adma.201000307

Acetal-modified dextran microparticles with controlled degradation kinetics and surface functionality for gene delivery in phagocytic and non-phagocytic cells

Joel A. Cohen, Tristan T. Beaudette, Jessica L. Cohen, Kyle E. Broaders, Eric M. Bachelder, Jean M.J. Fréchet

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

Figure Presented A microparticulate gene delivery system based on biodegradable and acid-sensitive acetal-modified dextran with unprecedented tunability of degradation rates and simplicity of surface functionalization is presented. When optimally formulated with small amounts of cationic polymers, these microparticles are capable of efficiently transfecting both phagocytic and nonphagocytic cells with minimal toxicity.

Original language	English (US)
Pages (from-to)	3593-3597
Number of pages	5
Journal	Advanced Materials
Volume	22
Issue number	32
DOIs	https://doi.org/10.1002/adma.201000307
State	Published - Aug 24 2010

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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abstract = "Figure Presented A microparticulate gene delivery system based on biodegradable and acid-sensitive acetal-modified dextran with unprecedented tunability of degradation rates and simplicity of surface functionalization is presented. When optimally formulated with small amounts of cationic polymers, these microparticles are capable of efficiently transfecting both phagocytic and nonphagocytic cells with minimal toxicity.",

author = "Cohen, {Joel A.} and Beaudette, {Tristan T.} and Cohen, {Jessica L.} and Broaders, {Kyle E.} and Bachelder, {Eric M.} and Fr{\'e}chet, {Jean M.J.}",

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T1 - Acetal-modified dextran microparticles with controlled degradation kinetics and surface functionality for gene delivery in phagocytic and non-phagocytic cells

AU - Cohen, Joel A.

AU - Beaudette, Tristan T.

AU - Cohen, Jessica L.

AU - Broaders, Kyle E.

AU - Bachelder, Eric M.

AU - Fréchet, Jean M.J.

PY - 2010/8/24

Y1 - 2010/8/24

N2 - Figure Presented A microparticulate gene delivery system based on biodegradable and acid-sensitive acetal-modified dextran with unprecedented tunability of degradation rates and simplicity of surface functionalization is presented. When optimally formulated with small amounts of cationic polymers, these microparticles are capable of efficiently transfecting both phagocytic and nonphagocytic cells with minimal toxicity.

AB - Figure Presented A microparticulate gene delivery system based on biodegradable and acid-sensitive acetal-modified dextran with unprecedented tunability of degradation rates and simplicity of surface functionalization is presented. When optimally formulated with small amounts of cationic polymers, these microparticles are capable of efficiently transfecting both phagocytic and nonphagocytic cells with minimal toxicity.

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U2 - 10.1002/adma.201000307

DO - 10.1002/adma.201000307

M3 - Article

C2 - 20518040

AN - SCOPUS:77955766504

SN - 0935-9648

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SP - 3593

EP - 3597

JO - Advanced Materials

JF - Advanced Materials

IS - 32

ER -

Acetal-modified dextran microparticles with controlled degradation kinetics and surface functionality for gene delivery in phagocytic and non-phagocytic cells

Abstract

ASJC Scopus subject areas

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