Acid-degradable cationic dextran particles for the delivery of siRNA therapeutics

Jessica L. Cohen, Stephanie Schubert, Peter R. Wich, Lina Cui, Joel A. Cohen, Justin L. Mynar, Jean M.J. Fréchet

Research output: Contribution to journalArticlepeer-review

134 Scopus citations


We report a new acid-sensitive, biocompatible, and biodegradable microparticulate delivery system, spermine modified acetalated-dextran (Spermine-Ac-DEX), which can be used to efficiently encapsulate siRNA. These particles demonstrated efficient gene knockdown in HeLa-luc cells with minimal toxicity. This knockdown was comparable to that obtained using Lipofectamine, a commercially available transfection reagent generally limited to in vitro use due to its high toxicity.

Original languageEnglish (US)
Pages (from-to)1056-1065
Number of pages10
JournalBioconjugate Chemistry
Issue number6
StatePublished - Jun 15 2011

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry


Dive into the research topics of 'Acid-degradable cationic dextran particles for the delivery of siRNA therapeutics'. Together they form a unique fingerprint.

Cite this