Acid-degradable solid-walled microcapsules for pH-responsive burst-release drug delivery

Kyle E. Broaders; Stefan J. Pastine; Sirisha Grandhe; Jean Frechet

doi:10.1039/c0cc04190d

Acid-degradable solid-walled microcapsules for pH-responsive burst-release drug delivery

Kyle E. Broaders, Stefan J. Pastine, Sirisha Grandhe, Jean Frechet

Physical Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

Acid-degradable microcapsules were prepared via an interfacial polymerization. Degradation of the thin wall of the capsules leads to all-or-nothing cargo release. The only byproducts of degradation are acetone, and a non-toxic triamide. Proof-of-concept experiments showed that cargo can be delivered to and released in cells.

Original language	English (US)
Pages (from-to)	665-667
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	2
DOIs	https://doi.org/10.1039/c0cc04190d
State	Published - Jan 14 2011

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c0cc04190d

Cite this

@article{7bcaf1697825452c9f13c8b4119bdf34,

title = "Acid-degradable solid-walled microcapsules for pH-responsive burst-release drug delivery",

abstract = "Acid-degradable microcapsules were prepared via an interfacial polymerization. Degradation of the thin wall of the capsules leads to all-or-nothing cargo release. The only byproducts of degradation are acetone, and a non-toxic triamide. Proof-of-concept experiments showed that cargo can be delivered to and released in cells.",

author = "Broaders, {Kyle E.} and Pastine, {Stefan J.} and Sirisha Grandhe and Jean Frechet",

year = "2011",

month = jan,

day = "14",

doi = "10.1039/c0cc04190d",

language = "English (US)",

volume = "47",

pages = "665--667",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "ROYAL SOC CHEMISTRY",

number = "2",

}

TY - JOUR

T1 - Acid-degradable solid-walled microcapsules for pH-responsive burst-release drug delivery

AU - Broaders, Kyle E.

AU - Pastine, Stefan J.

AU - Grandhe, Sirisha

AU - Frechet, Jean

PY - 2011/1/14

Y1 - 2011/1/14

N2 - Acid-degradable microcapsules were prepared via an interfacial polymerization. Degradation of the thin wall of the capsules leads to all-or-nothing cargo release. The only byproducts of degradation are acetone, and a non-toxic triamide. Proof-of-concept experiments showed that cargo can be delivered to and released in cells.

AB - Acid-degradable microcapsules were prepared via an interfacial polymerization. Degradation of the thin wall of the capsules leads to all-or-nothing cargo release. The only byproducts of degradation are acetone, and a non-toxic triamide. Proof-of-concept experiments showed that cargo can be delivered to and released in cells.

UR - http://www.scopus.com/inward/record.url?scp=78651403536&partnerID=8YFLogxK

U2 - 10.1039/c0cc04190d

DO - 10.1039/c0cc04190d

M3 - Article

C2 - 21113530

AN - SCOPUS:78651403536

SN - 1359-7345

VL - 47

SP - 665

EP - 667

JO - Chemical Communications

JF - Chemical Communications

IS - 2

ER -

Acid-degradable solid-walled microcapsules for pH-responsive burst-release drug delivery

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this