Acid-degradable solid-walled microcapsules for pH-responsive burst-release drug delivery

Kyle E. Broaders, Stefan J. Pastine, Sirisha Grandhe, Jean Frechet

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


Acid-degradable microcapsules were prepared via an interfacial polymerization. Degradation of the thin wall of the capsules leads to all-or-nothing cargo release. The only byproducts of degradation are acetone, and a non-toxic triamide. Proof-of-concept experiments showed that cargo can be delivered to and released in cells.

Original languageEnglish (US)
Pages (from-to)665-667
Number of pages3
JournalChemical Communications
Issue number2
StatePublished - Jan 14 2011

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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