Acid-degradable solid-walled microcapsules for pH-responsive burst-release drug delivery

Kyle E. Broaders; Stefan J. Pastine; Sirisha Grandhe; Jean M.J. Fréchet

doi:10.1039/c0cc04190d

Acid-degradable solid-walled microcapsules for pH-responsive burst-release drug delivery

Kyle E. Broaders, Stefan J. Pastine, Sirisha Grandhe, Jean M.J. Fréchet^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

Acid-degradable microcapsules were prepared via an interfacial polymerization. Degradation of the thin wall of the capsules leads to all-or-nothing cargo release. The only byproducts of degradation are acetone, and a non-toxic triamide. Proof-of-concept experiments showed that cargo can be delivered to and released in cells.

Original language	English (US)
Pages (from-to)	665-667
Number of pages	3
Journal	CHEMICAL COMMUNICATIONS
Volume	47
Issue number	2
DOIs	https://doi.org/10.1039/c0cc04190d
State	Published - Dec 14 2011

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "Acid-degradable microcapsules were prepared via an interfacial polymerization. Degradation of the thin wall of the capsules leads to all-or-nothing cargo release. The only byproducts of degradation are acetone, and a non-toxic triamide. Proof-of-concept experiments showed that cargo can be delivered to and released in cells.",

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Acid-degradable solid-walled microcapsules for pH-responsive burst-release drug delivery

Abstract

ASJC Scopus subject areas

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