Action of heptaminol hydrochloride on contractile properties in frog isolated twitch muscle fibre

Bruno Allard; Vincent Jacquemond; Fouad Lemtiri‐Chlieh; Bernard Pourrias; Oger Rougier

doi:10.1111/j.1476-5381.1991.tb12493.x

Action of heptaminol hydrochloride on contractile properties in frog isolated twitch muscle fibre

Bruno Allard^*, Vincent Jacquemond, Fouad Lemtiri‐Chlieh, Bernard Pourrias, Oger Rougier

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Heptaminol stopped or delayed the progressive decline in tension which characterizes the phenomenon of fatigue in frog isolated twitch muscle fibre. Heptaminol had no action on the sodium, potassium and calcium voltage‐dependent ionic conductances. The hypothesis of an action via an internal alkalinization was tested by comparison with the action of NH₄Cl. Both substances increased the tension. The action of heptaminol was suppressed in sodium‐free (TRIS) solution or in the presence of amiloride while the action of NH₄Cl was always observed. These results could be explained by a stimulation of the Na/H antiport by heptaminol. 1991 British Pharmacological Society

Original language	English (US)
Pages (from-to)	714-718
Number of pages	5
Journal	British Journal of Pharmacology
Volume	104
Issue number	3
DOIs	https://doi.org/10.1111/j.1476-5381.1991.tb12493.x
State	Published - Nov 1991
Externally published	Yes

Keywords

Heptaminol
excitation‐contraction coupling
fatigue
frog twitch muscle fibre

ASJC Scopus subject areas

Pharmacology

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10.1111/j.1476-5381.1991.tb12493.x

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abstract = "Heptaminol stopped or delayed the progressive decline in tension which characterizes the phenomenon of fatigue in frog isolated twitch muscle fibre. Heptaminol had no action on the sodium, potassium and calcium voltage‐dependent ionic conductances. The hypothesis of an action via an internal alkalinization was tested by comparison with the action of NH4Cl. Both substances increased the tension. The action of heptaminol was suppressed in sodium‐free (TRIS) solution or in the presence of amiloride while the action of NH4Cl was always observed. These results could be explained by a stimulation of the Na/H antiport by heptaminol. 1991 British Pharmacological Society",

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T1 - Action of heptaminol hydrochloride on contractile properties in frog isolated twitch muscle fibre

AU - Allard, Bruno

AU - Jacquemond, Vincent

AU - Lemtiri‐Chlieh, Fouad

AU - Pourrias, Bernard

AU - Rougier, Oger

PY - 1991/11

Y1 - 1991/11

N2 - Heptaminol stopped or delayed the progressive decline in tension which characterizes the phenomenon of fatigue in frog isolated twitch muscle fibre. Heptaminol had no action on the sodium, potassium and calcium voltage‐dependent ionic conductances. The hypothesis of an action via an internal alkalinization was tested by comparison with the action of NH4Cl. Both substances increased the tension. The action of heptaminol was suppressed in sodium‐free (TRIS) solution or in the presence of amiloride while the action of NH4Cl was always observed. These results could be explained by a stimulation of the Na/H antiport by heptaminol. 1991 British Pharmacological Society

AB - Heptaminol stopped or delayed the progressive decline in tension which characterizes the phenomenon of fatigue in frog isolated twitch muscle fibre. Heptaminol had no action on the sodium, potassium and calcium voltage‐dependent ionic conductances. The hypothesis of an action via an internal alkalinization was tested by comparison with the action of NH4Cl. Both substances increased the tension. The action of heptaminol was suppressed in sodium‐free (TRIS) solution or in the presence of amiloride while the action of NH4Cl was always observed. These results could be explained by a stimulation of the Na/H antiport by heptaminol. 1991 British Pharmacological Society

KW - Heptaminol

KW - excitation‐contraction coupling

KW - fatigue

KW - frog twitch muscle fibre

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Action of heptaminol hydrochloride on contractile properties in frog isolated twitch muscle fibre

Abstract

Keywords

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