TY - GEN
T1 - Acute Changes in P-Wave Morphology by Pulmonary Vein Isolation in Atrial Fibrillation Patients
AU - Gharaviri, Ali
AU - Zink, Matthias
AU - Potse, Mark
AU - Pezzuto, Simone
AU - Zeemering, Stef
AU - Krause, Rolf
AU - Auricchio, Angelo
AU - Schotten, Ulrich
N1 - Publisher Copyright:
© 2018 Creative Commons Attribution.
PY - 2018/9
Y1 - 2018/9
N2 - Pulmonary vein (PV) plays an important role in atrial fibrillation (AF) initiation, progression, and stability. Successful PV isolation (PVI), either by radiofrequency catheter or Cryoballoon ablation, may terminate AF and prevent its recurrence. Whereas, incomplete PV isolation or reconnection of isolated PVs underlies mechanisms of AF recurrence. Hence, defining parameters able to predict a successful PVI and detect reconnections can assist clinicians in treatment of AF patients. Here, we developed a highly detailed human atrial model to simulate PVI and its acute effect on the P-wave morphology. Afterwards, the simulation results were compared and validated by recorded ECGs from patients before and after PVI procedure. In both simulation data and clinical recordings, we observed morphological changes in P-wave after PVI. More importantly our simulation helped us to find electrode positions, in which the differences in P-wave morphology before and after PVI were more pronounced.
AB - Pulmonary vein (PV) plays an important role in atrial fibrillation (AF) initiation, progression, and stability. Successful PV isolation (PVI), either by radiofrequency catheter or Cryoballoon ablation, may terminate AF and prevent its recurrence. Whereas, incomplete PV isolation or reconnection of isolated PVs underlies mechanisms of AF recurrence. Hence, defining parameters able to predict a successful PVI and detect reconnections can assist clinicians in treatment of AF patients. Here, we developed a highly detailed human atrial model to simulate PVI and its acute effect on the P-wave morphology. Afterwards, the simulation results were compared and validated by recorded ECGs from patients before and after PVI procedure. In both simulation data and clinical recordings, we observed morphological changes in P-wave after PVI. More importantly our simulation helped us to find electrode positions, in which the differences in P-wave morphology before and after PVI were more pronounced.
UR - http://www.scopus.com/inward/record.url?scp=85067200564&partnerID=8YFLogxK
U2 - 10.22489/CinC.2018.034
DO - 10.22489/CinC.2018.034
M3 - Conference contribution
AN - SCOPUS:85067200564
T3 - Computing in Cardiology
BT - Computing in Cardiology Conference, CinC 2018
PB - IEEE Computer Society
T2 - 45th Computing in Cardiology Conference, CinC 2018
Y2 - 23 September 2018 through 26 September 2018
ER -