Adenosine triphosphate and arachidonic acid stimulate glycogenolysis in primary cultures of mouse cerebral cortical astrocytes

Olivier Sorg; Luc Pellerin; Marc Stolz; Siham Beggah; Pierre J. Magistretti

doi:10.1016/0304-3940(95)11410-X

Adenosine triphosphate and arachidonic acid stimulate glycogenolysis in primary cultures of mouse cerebral cortical astrocytes

Olivier Sorg, Luc Pellerin, Marc Stolz, Siham Beggah, Pierre J. Magistretti^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Adenosine triphosphate (ATP) promotes glycogenolysis in primary cultures of mouse cerebral cortical astrocytes with an EC₅₀ of 1.5 μM. A pharmacological analysis indicates an involvement of purinergic P_2Y receptors in this action of ATP Application of either arachidonic acid (AA), or certain unsaturated fatty acids, also results in glycogen breakdown. The EC₅₀ of AA is approximately 50 μM. Thus ATP and AA can be added to the list of neuroactive agents that control glycogen levels in astrocytes, which includes noradrenaline, vasoactive intestinal peptide (VIP), adenosine and histamine.

Original language	English (US)
Pages (from-to)	109-112
Number of pages	4
Journal	Neuroscience Letters
Volume	188
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(95)11410-X
State	Published - Mar 24 1995
Externally published	Yes

Keywords

ATP
Arachidonic acid
Astrocytes
Energy metabolism
Glycogen
Purinergic

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(95)11410-X

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abstract = "Adenosine triphosphate (ATP) promotes glycogenolysis in primary cultures of mouse cerebral cortical astrocytes with an EC50 of 1.5 μM. A pharmacological analysis indicates an involvement of purinergic P2Y receptors in this action of ATP Application of either arachidonic acid (AA), or certain unsaturated fatty acids, also results in glycogen breakdown. The EC50 of AA is approximately 50 μM. Thus ATP and AA can be added to the list of neuroactive agents that control glycogen levels in astrocytes, which includes noradrenaline, vasoactive intestinal peptide (VIP), adenosine and histamine.",

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AU - Sorg, Olivier

AU - Pellerin, Luc

AU - Stolz, Marc

AU - Beggah, Siham

AU - Magistretti, Pierre J.

PY - 1995/3/24

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N2 - Adenosine triphosphate (ATP) promotes glycogenolysis in primary cultures of mouse cerebral cortical astrocytes with an EC50 of 1.5 μM. A pharmacological analysis indicates an involvement of purinergic P2Y receptors in this action of ATP Application of either arachidonic acid (AA), or certain unsaturated fatty acids, also results in glycogen breakdown. The EC50 of AA is approximately 50 μM. Thus ATP and AA can be added to the list of neuroactive agents that control glycogen levels in astrocytes, which includes noradrenaline, vasoactive intestinal peptide (VIP), adenosine and histamine.

AB - Adenosine triphosphate (ATP) promotes glycogenolysis in primary cultures of mouse cerebral cortical astrocytes with an EC50 of 1.5 μM. A pharmacological analysis indicates an involvement of purinergic P2Y receptors in this action of ATP Application of either arachidonic acid (AA), or certain unsaturated fatty acids, also results in glycogen breakdown. The EC50 of AA is approximately 50 μM. Thus ATP and AA can be added to the list of neuroactive agents that control glycogen levels in astrocytes, which includes noradrenaline, vasoactive intestinal peptide (VIP), adenosine and histamine.

KW - ATP

KW - Arachidonic acid

KW - Astrocytes

KW - Energy metabolism

KW - Glycogen

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Adenosine triphosphate and arachidonic acid stimulate glycogenolysis in primary cultures of mouse cerebral cortical astrocytes

Abstract

Keywords

ASJC Scopus subject areas

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