TY - JOUR
T1 - Adrenal steroid concentrations in children seven to seventeen years of age
AU - Meikle, A. Wayne
AU - Kushnir, Mark M.
AU - Rockwood, Alan L.
AU - Pattison, Elizabeth G.
AU - Terry, Alan H.
AU - Sandrock, Tonya
AU - Bunker, Ashley M.
AU - Phanslkar, Amit R.
AU - Owen, William E.
AU - Roberts, William L.
N1 - Generated from Scopus record by KAUST IRTS on 2023-09-20
PY - 2007/1/1
Y1 - 2007/1/1
N2 - During puberty, serum steroid concentrations change dramatically. The objective of this study was to determine the adrenal steroid concentrations in children from 7 to 17 years of age. Tanner stage was determined in each child by physical examination. 11-Deoxycortisol, pregnenolone, 17-hydroxypregnenolone, 17-hydroxy-progesterone and testosterone were quantified by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Androstenedione and dehydroepiandrosterone sulfate were measured by immunoassay. The median and central 95% of the steroid concentrations were determined for age, gender, and Tanner stage. Except for 11-deoxycortisol, all of the steroids exhibited an increase in concentration after age 7-9 years in both boys and girls, 11-Deoxycortisol, which is made exclusively in the adrenal cortex, declined with age and Tanner stage. This suggests that a rise in gonadal function and decreased efficiency of 11β-hydroxylase with age may contribute to an increase in the remaining steroids. Testosterone concentrations increased more dramatically in boys, but increases were seen with each Tanner stage in girls. © Freund Publishing House Ltd., London.
AB - During puberty, serum steroid concentrations change dramatically. The objective of this study was to determine the adrenal steroid concentrations in children from 7 to 17 years of age. Tanner stage was determined in each child by physical examination. 11-Deoxycortisol, pregnenolone, 17-hydroxypregnenolone, 17-hydroxy-progesterone and testosterone were quantified by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Androstenedione and dehydroepiandrosterone sulfate were measured by immunoassay. The median and central 95% of the steroid concentrations were determined for age, gender, and Tanner stage. Except for 11-deoxycortisol, all of the steroids exhibited an increase in concentration after age 7-9 years in both boys and girls, 11-Deoxycortisol, which is made exclusively in the adrenal cortex, declined with age and Tanner stage. This suggests that a rise in gonadal function and decreased efficiency of 11β-hydroxylase with age may contribute to an increase in the remaining steroids. Testosterone concentrations increased more dramatically in boys, but increases were seen with each Tanner stage in girls. © Freund Publishing House Ltd., London.
UR - https://www.degruyter.com/document/doi/10.1515/JPEM.2007.20.12.1281/html
UR - http://www.scopus.com/inward/record.url?scp=38049100716&partnerID=8YFLogxK
U2 - 10.1515/JPEM.2007.20.12.1281
DO - 10.1515/JPEM.2007.20.12.1281
M3 - Article
SN - 0334-018X
VL - 20
SP - 1281
EP - 1291
JO - Journal of Pediatric Endocrinology and Metabolism
JF - Journal of Pediatric Endocrinology and Metabolism
IS - 12
ER -
