@inproceedings{3c126202d97d4c54a783c8fd0ccd2556,
title = "Advancing Transdermal Therapeutics: In-Vivo Assessment and Computational Insights into Porous Microneedle-Based Drug Delivery",
abstract = "Porous microneedles (MN) offer the advantage of allowing for higher dosage delivery because of their larger surface area and broader diffusion spread compared to topical delivery. In this study, porous MNs were fabricated using two-photon polymerization. We simulated the diffusion of fluorescein isothiocyanate (FITC)-dextran as a pseudo drug through the skin with and without the porous MN and proved that at a depth of 100?m in the dermis, the porous MN delivers over 4 times the concentration of FITC-dextran compared to topical delivery. We also performed an in vivo study on mouse skin by delivering a fast green FCF stain through a 5 × 5 array of porous MNs. The dye was successfully delivered, and the array remained intact after insertion.",
keywords = "drug delivery, in-vivo, microneedles, simulation",
author = "Esraa Fakeih and {Al Sulaiman}, Dana and Salama, {Khaled Nabil}",
note = "Publisher Copyright: {\textcopyright} 2023 IEEE.; 2023 IEEE SENSORS, SENSORS 2023 ; Conference date: 29-10-2023 Through 01-11-2023",
year = "2023",
doi = "10.1109/SENSORS56945.2023.10325189",
language = "English (US)",
series = "Proceedings of IEEE Sensors",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
booktitle = "2023 IEEE SENSORS, SENSORS 2023 - Conference Proceedings",
address = "United States",
}