African origin of GB virus C/hepatitis G virus

Yasuhito Tanaka; Masashi Mizokami; Etsuro Orito; Ken ichi Ohba; Takanobu Kato; Yutaka Kondo; Innocent Mboudjeka; Leopold Zekeng; Lazare Kaptue; Blaise Bikandou; Pierre M'Pele; Jun Takehisa; Masanori Hayami; Yoshiyuki Suzuki; Takashi Gojobori

doi:10.1016/S0014-5793(98)00083-0

African origin of GB virus C/hepatitis G virus

Yasuhito Tanaka, Masashi Mizokami^*, Etsuro Orito, Ken ichi Ohba, Takanobu Kato, Yutaka Kondo, Innocent Mboudjeka, Leopold Zekeng, Lazare Kaptue, Blaise Bikandou, Pierre M'Pele, Jun Takehisa, Masanori Hayami, Yoshiyuki Suzuki, Takashi Gojobori

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Ninety-four GB virus C/hepatitis G virus (GBV-C/HGV) RNA-positive serum samples were obtained from all over the world. We found that all 15 GBV- C/HGV isolates from the Pygmies and the Bantu in the Central African region had a 12-amino acid indel (i.e. insertion or deletion) in the non-structural protein (NS) 5A region. Phylogenetic analyses of the NS5A region, using GBV- A as an outgroup, showed that these 15 isolates had diverged from the common ancestor much earlier than the remaining isolates, indicating an African origin of GBVC/HGV.

Original language	English (US)
Pages (from-to)	143-148
Number of pages	6
Journal	FEBS Letters
Volume	423
Issue number	2
DOIs	https://doi.org/10.1016/S0014-5793(98)00083-0
State	Published - Feb 20 1998
Externally published	Yes

Keywords

Africa
GB virus C
Hepatitis G virus
Indel
NS5A
Phylogenetic analysis
Pygmy

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0014-5793(98)00083-0

Cite this

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title = "African origin of GB virus C/hepatitis G virus",

abstract = "Ninety-four GB virus C/hepatitis G virus (GBV-C/HGV) RNA-positive serum samples were obtained from all over the world. We found that all 15 GBV- C/HGV isolates from the Pygmies and the Bantu in the Central African region had a 12-amino acid indel (i.e. insertion or deletion) in the non-structural protein (NS) 5A region. Phylogenetic analyses of the NS5A region, using GBV- A as an outgroup, showed that these 15 isolates had diverged from the common ancestor much earlier than the remaining isolates, indicating an African origin of GBVC/HGV.",

keywords = "Africa, GB virus C, Hepatitis G virus, Indel, NS5A, Phylogenetic analysis, Pygmy",

author = "Yasuhito Tanaka and Masashi Mizokami and Etsuro Orito and Ohba, {Ken ichi} and Takanobu Kato and Yutaka Kondo and Innocent Mboudjeka and Leopold Zekeng and Lazare Kaptue and Blaise Bikandou and Pierre M'Pele and Jun Takehisa and Masanori Hayami and Yoshiyuki Suzuki and Takashi Gojobori",

year = "1998",

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day = "20",

doi = "10.1016/S0014-5793(98)00083-0",

language = "English (US)",

volume = "423",

pages = "143--148",

journal = "FEBS Letters",

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}

TY - JOUR

T1 - African origin of GB virus C/hepatitis G virus

AU - Tanaka, Yasuhito

AU - Mizokami, Masashi

AU - Orito, Etsuro

AU - Ohba, Ken ichi

AU - Kato, Takanobu

AU - Kondo, Yutaka

AU - Mboudjeka, Innocent

AU - Zekeng, Leopold

AU - Kaptue, Lazare

AU - Bikandou, Blaise

AU - M'Pele, Pierre

AU - Takehisa, Jun

AU - Hayami, Masanori

AU - Suzuki, Yoshiyuki

AU - Gojobori, Takashi

PY - 1998/2/20

Y1 - 1998/2/20

N2 - Ninety-four GB virus C/hepatitis G virus (GBV-C/HGV) RNA-positive serum samples were obtained from all over the world. We found that all 15 GBV- C/HGV isolates from the Pygmies and the Bantu in the Central African region had a 12-amino acid indel (i.e. insertion or deletion) in the non-structural protein (NS) 5A region. Phylogenetic analyses of the NS5A region, using GBV- A as an outgroup, showed that these 15 isolates had diverged from the common ancestor much earlier than the remaining isolates, indicating an African origin of GBVC/HGV.

AB - Ninety-four GB virus C/hepatitis G virus (GBV-C/HGV) RNA-positive serum samples were obtained from all over the world. We found that all 15 GBV- C/HGV isolates from the Pygmies and the Bantu in the Central African region had a 12-amino acid indel (i.e. insertion or deletion) in the non-structural protein (NS) 5A region. Phylogenetic analyses of the NS5A region, using GBV- A as an outgroup, showed that these 15 isolates had diverged from the common ancestor much earlier than the remaining isolates, indicating an African origin of GBVC/HGV.

KW - Africa

KW - GB virus C

KW - Hepatitis G virus

KW - Indel

KW - NS5A

KW - Phylogenetic analysis

KW - Pygmy

UR - http://www.scopus.com/inward/record.url?scp=17344387666&partnerID=8YFLogxK

U2 - 10.1016/S0014-5793(98)00083-0

DO - 10.1016/S0014-5793(98)00083-0

M3 - Article

C2 - 9512347

AN - SCOPUS:17344387666

SN - 0014-5793

VL - 423

SP - 143

EP - 148

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

African origin of GB virus C/hepatitis G virus

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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