Abstract
Ninety-four GB virus C/hepatitis G virus (GBV-C/HGV) RNA-positive serum samples were obtained from all over the world. We found that all 15 GBV- C/HGV isolates from the Pygmies and the Bantu in the Central African region had a 12-amino acid indel (i.e. insertion or deletion) in the non-structural protein (NS) 5A region. Phylogenetic analyses of the NS5A region, using GBV- A as an outgroup, showed that these 15 isolates had diverged from the common ancestor much earlier than the remaining isolates, indicating an African origin of GBVC/HGV.
Original language | English (US) |
---|---|
Pages (from-to) | 143-148 |
Number of pages | 6 |
Journal | FEBS Letters |
Volume | 423 |
Issue number | 2 |
DOIs | |
State | Published - Feb 20 1998 |
Externally published | Yes |
Keywords
- Africa
- GB virus C
- Hepatitis G virus
- Indel
- NS5A
- Phylogenetic analysis
- Pygmy
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology