Abstract
Half-sandwich iridium complexes bearing bidentate urea-phosphorus ligands were found to catalyze the direct reductive amination of aromatic and aliphatic ketones under mild conditions at 0.5 mol.% loading with high selectivity towards primary amines. One of the complexes was found to be active in both the Leuckart-Wallach (NH4CO2H) type reaction as well as in the hydrogenative (H2/NH4AcO) reductive amination. The protocol with ammonium formate does not require an inert atmosphere, dry solvents, as well as additives and in contrast to previous reports takes place in HFIP instead of methanol. Applying NH4CO2D or D2 resulted in a high degree of deuterium incorporation into the primary amine α-position.
| Original language | English (US) |
|---|---|
| Journal | Chemistry (Weinheim an der Bergstrasse, Germany) |
| DOIs | |
| State | Published - Jan 28 2021 |
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CCDC 2064119: Experimental Crystal Structure Determination : ([(6H-dibenzo[d,f][1,3,2]dioxaphosphepin-6-yl)(methyl)carbamoyl](methyl)amido)-(eta5-pentamethylcyclopentadienyl)-chloro-iridium monohydrate
Lebedev, Y. (Creator), Rueping, M. (Creator), Polishchuk, I. (Creator) & Sklyaruk, J. (Creator), Cambridge Crystallographic Data Centre, Feb 21 2021
DOI: 10.5517/ccdc.csd.cc278whx, http://hdl.handle.net/10754/669030
Dataset
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CCDC 2064118: Experimental Crystal Structure Determination :
Lebedev, Y. (Creator), Rueping, M. (Creator), Polishchuk, I. (Creator) & Sklyaruk, J. (Creator), Cambridge Crystallographic Data Centre, Feb 21 2021
DOI: 10.5517/ccdc.csd.cc278wgw, http://hdl.handle.net/10754/669024
Dataset