Abstract
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1015-1035 |
| Number of pages | 21 |
| Journal | The Lancet |
| Volume | 392 |
| Issue number | 10152 |
| DOIs | |
| State | Published - Sep 22 2018 |
ASJC Scopus subject areas
- General Medicine
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In: The Lancet, Vol. 392, No. 10152, 22.09.2018, p. 1015-1035.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Alcohol use and burden for 195 countries and territories, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016
AU - Griswold, Max G.
AU - Fullman, Nancy
AU - Hawley, Caitlin
AU - Arian, Nicholas
AU - Zimsen, Stephanie R.M.
AU - Tymeson, Hayley D.
AU - Venkateswaran, Vidhya
AU - Tapp, Austin Douglas
AU - Forouzanfar, Mohammad H.
AU - Salama, Joseph S.
AU - Abate, Kalkidan Hassen
AU - Abate, Degu
AU - Abay, Solomon M.
AU - Abbafati, Cristiana
AU - Abdulkader, Rizwan Suliankatchi
AU - Abebe, Zegeye
AU - Aboyans, Victor
AU - Abrar, Mohammed Mehdi
AU - Acharya, Pawan
AU - Adetokunboh, Olatunji O.
AU - Adhikari, Tara Ballav
AU - Adsuar, Jose C.
AU - Afarideh, Mohsen
AU - Agardh, Emilie Elisabet
AU - Agarwal, Gina
AU - Aghayan, Sargis Aghasi
AU - Agrawal, Sutapa
AU - Ahmed, Muktar Beshir
AU - Akibu, Mohammed
AU - Akinyemiju, Tomi
AU - Akseer, Nadia
AU - Al Asfoor, Deena H.
AU - Al-Aly, Ziyad
AU - Alahdab, Fares
AU - Alam, Khurshid
AU - Albujeer, Ammar
AU - Alene, Kefyalew Addis
AU - Ali, Raghib
AU - Ali, Syed Danish
AU - Alijanzadeh, Mehran
AU - Aljunid, Syed Mohamed
AU - Alkerwi, Ala'A
AU - Allebeck, Peter
AU - Alvis-Guzman, Nelson
AU - Amare, Azmeraw T.
AU - Aminde, Leopold N.
AU - Ammar, Walid
AU - Amoako, Yaw Ampem
AU - Amul, Gianna Gayle Herrera
AU - Andrei, Catalina Liliana
AU - Angus, Colin
AU - Ansha, Mustafa Geleto
AU - Antonio, Carl Abelardo T.
AU - Aremu, Olatunde
AU - Ärnlöv, Johan
AU - Artaman, Al
AU - Aryal, Krishna K.
AU - Assadi, Reza
AU - Ausloos, Marcel
AU - Avila-Burgos, Leticia
AU - Avokpaho, Euripide F.G.A.
AU - Awasthi, Ashish
AU - Ayele, Henok Tadesse
AU - Ayer, Rakesh
AU - Ayuk, Tambe B.
AU - Azzopardi, Peter S.
AU - Badali, Hamid
AU - Badawi, Alaa
AU - Banach, Maciej
AU - Barker-Collo, Suzanne Lyn
AU - Barrero, Lope H.
AU - Basaleem, Huda
AU - Baye, Estifanos
AU - Bazargan-Hejazi, Shahrzad
AU - Bedi, Neeraj
AU - Béjot, Yannick
AU - Belachew, Abate Bekele
AU - Belay, Saba Abraham
AU - Bennett, Derrick A.
AU - Bensenor, Isabela M.
AU - Bernabe, Eduardo
AU - Bernstein, Robert S.
AU - Beyene, Addisu Shunu
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AU - Bhutta, Zulfiqar A.
AU - Biadgo, Belete
AU - Bijani, Ali
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AU - Bjerregaard, Peter
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AU - Bosetti, Cristina
AU - Boufous, Soufiane
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AU - Brenner, Hermann
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AU - Cahuana-Hurtado, Lucero
AU - Calabria, Bianca
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AU - Hagos, Tekleberhan Beyene
AU - Hailu, Gessessew Bugssa
AU - Hamadeh, Randah R.
AU - Hamidi, Samer
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AU - Haro, Josep Maria
AU - Hassen, Hamid Yimam
AU - Havmoeller, Rasmus
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AU - Henok, Andualem
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AU - Hernández-Llanes, Norberto Francisco
AU - Herteliu, Claudiu
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AU - Kahsay, Amaha
AU - Kapil, Umesh
AU - Kasaeian, Amir
AU - Kassa, Tesfaye D.Dessale
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AU - Kebede, Seifu
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AU - Keiyoro, Peter Njenga
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AU - Khan, Md Nuruzzaman
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AU - Khubchandani, Jagdish
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AU - Kivimäki, Mika
AU - Kochhar, Sonali
AU - Kosen, Soewarta
AU - Koul, Parvaiz A.
AU - Koyanagi, Ai
AU - Krishan, Kewal
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AU - Bicer, Burcu Kucuk
AU - Kulkarni, Veena S.
AU - Kumar, Pushpendra
AU - Lafranconi, Alessandra
AU - Balaji, Arjun Lakshmana
AU - Lalloo, Ratilal
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AU - Lang, Justin J.
AU - Lansky, Sonia
AU - Larsson, Anders O.
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AU - Levi, Miriam
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AU - Liu, Shiwei
AU - Lobato-Cordero, Andrea
AU - Lopez, Alan D.
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AU - Majeed, Azeem
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AU - Mapoma, Chabila Christopher
AU - Martinez-Raga, Jose
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N1 - Generated from Scopus record by KAUST IRTS on 2021-03-16
PY - 2018/9/22
Y1 - 2018/9/22
N2 - Background: Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions. With our comprehensive approach to health accounting within the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we generated improved estimates of alcohol use and alcohol-attributable deaths and disability-adjusted lifeyears (DALYs) for 195 locations from 1990 to 2016, for both sexes and for 5-year age groups between the ages of 15 years and 95 years and older. Methods: Using 694 data sources of individual and population-level alcohol consumption, along with 592 prospective and retrospective studies on the risk of alcohol use, we produced estimates of the prevalence of current drinking, abstention, the distribution of alcohol consumption among current drinkers in standard drinks daily (defined as 10 g of pure ethyl alcohol), and alcohol-attributable deaths and DALYs. We made several methodological improvements compared with previous estimates: first, we adjusted alcohol sales estimates to take into account tourist and unrecorded consumption; second, we did a new meta-analysis of relative risks for 23 health outcomes associated with alcohol use; and third, we developed a new method to quantify the level of alcohol consumption that minimises the overall risk to individual health. Findings: Globally, alcohol use was the seventh leading risk factor for both deaths and DALYs in 2016, accounting for 2·2% (95% uncertainty interval [UI] 1·5-3·0) of age-standardised female deaths and 6·8% (5·8-8·0) of agestandardised male deaths. Among the population aged 15-49 years, alcohol use was the leading risk factor globally in 2016, with 3·8% (95% UI 3·2-4·3) of female deaths and 12·2% (10·8-13·6) of male deaths attributable to alcohol use. For the population aged 15-49 years, female attributable DALYs were 2·3% (95% UI 2·0-2·6) and male attributable DALYs were 8·9% (7·8-9·9). The three leading causes of attributable deaths in this age group were tuberculosis (1·4% [95% UI 1·0-1·7] of total deaths), road injuries (1·2% [0·7-1·9]), and self-harm (1·1% [0·6-1·5]). For populations aged 50 years and older, cancers accounted for a large proportion of total alcohol-attributable deaths in 2016, constituting 27·1% (95% UI 21·2-33·3) of total alcohol-attributable female deaths and 18·9% (15·3-22·6) of male deaths. The level of alcohol consumption that minimised harm across health outcomes was zero (95% UI 0·0-0·8) standard drinks per week. Interpretation: Alcohol use is a leading risk factor for global disease burden and causes substantial health loss. We found that the risk of all-cause mortality, and of cancers specifically, rises with increasing levels of consumption, and the level of consumption that minimises health loss is zero. These results suggest that alcohol control policies might need to be revised worldwide, refocusing on efforts to lower overall population-level consumption. Funding Bill & Melinda Gates Foundation.
AB - Background: Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions. With our comprehensive approach to health accounting within the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we generated improved estimates of alcohol use and alcohol-attributable deaths and disability-adjusted lifeyears (DALYs) for 195 locations from 1990 to 2016, for both sexes and for 5-year age groups between the ages of 15 years and 95 years and older. Methods: Using 694 data sources of individual and population-level alcohol consumption, along with 592 prospective and retrospective studies on the risk of alcohol use, we produced estimates of the prevalence of current drinking, abstention, the distribution of alcohol consumption among current drinkers in standard drinks daily (defined as 10 g of pure ethyl alcohol), and alcohol-attributable deaths and DALYs. We made several methodological improvements compared with previous estimates: first, we adjusted alcohol sales estimates to take into account tourist and unrecorded consumption; second, we did a new meta-analysis of relative risks for 23 health outcomes associated with alcohol use; and third, we developed a new method to quantify the level of alcohol consumption that minimises the overall risk to individual health. Findings: Globally, alcohol use was the seventh leading risk factor for both deaths and DALYs in 2016, accounting for 2·2% (95% uncertainty interval [UI] 1·5-3·0) of age-standardised female deaths and 6·8% (5·8-8·0) of agestandardised male deaths. Among the population aged 15-49 years, alcohol use was the leading risk factor globally in 2016, with 3·8% (95% UI 3·2-4·3) of female deaths and 12·2% (10·8-13·6) of male deaths attributable to alcohol use. For the population aged 15-49 years, female attributable DALYs were 2·3% (95% UI 2·0-2·6) and male attributable DALYs were 8·9% (7·8-9·9). The three leading causes of attributable deaths in this age group were tuberculosis (1·4% [95% UI 1·0-1·7] of total deaths), road injuries (1·2% [0·7-1·9]), and self-harm (1·1% [0·6-1·5]). For populations aged 50 years and older, cancers accounted for a large proportion of total alcohol-attributable deaths in 2016, constituting 27·1% (95% UI 21·2-33·3) of total alcohol-attributable female deaths and 18·9% (15·3-22·6) of male deaths. The level of alcohol consumption that minimised harm across health outcomes was zero (95% UI 0·0-0·8) standard drinks per week. Interpretation: Alcohol use is a leading risk factor for global disease burden and causes substantial health loss. We found that the risk of all-cause mortality, and of cancers specifically, rises with increasing levels of consumption, and the level of consumption that minimises health loss is zero. These results suggest that alcohol control policies might need to be revised worldwide, refocusing on efforts to lower overall population-level consumption. Funding Bill & Melinda Gates Foundation.
UR - https://linkinghub.elsevier.com/retrieve/pii/S0140673618313102
UR - http://www.scopus.com/inward/record.url?scp=85054381565&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(18)31310-2
DO - 10.1016/S0140-6736(18)31310-2
M3 - Article
SN - 1474-547X
VL - 392
SP - 1015
EP - 1035
JO - The Lancet
JF - The Lancet
IS - 10152
ER -