Alginate-based hybrid aerogel microparticles for mucosal drug delivery

V. S. S. Goncalves; P. Gurikov; J. Poejo; A. A. Matias; S. Heinrich; C. M. M. Duarte; I. Smirnova

doi:10.1016/j.ejpb.2016.07.003

Alginate-based hybrid aerogel microparticles for mucosal drug delivery

V. S. S. Goncalves, P. Gurikov^*, J. Poejo, A. A. Matias, S. Heinrich, C. M. M. Duarte, I. Smirnova

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

The application, of biopolymer aerogels as drug delivery systems (DDS) has gained increased interest during the last decade since these structures have large surface area and accessible pores allowing for high drug loadings. Being biocompatible, biodegradable and presenting low toxicity, polysaccharide-based aerogels are an attractive carrier to be applied in pharmaceutical industry. Moreover, some polysaccharides (e.g. alginate and chitosan) present mucoadhesive properties, an important feature for mucosal drug delivery. This feature allows to extend the contact of DDS with biological membranes, thereby increasing the absorption of drugs through the mucosa. Alginate-based hybrid aerogels in the form of microparticles (

Original language	English
Pages (from-to)	160-170
Number of pages	11
Journal	European Journal of Pharmaceutics and Biopharmaceutics
Volume	107
DOIs	https://doi.org/10.1016/j.ejpb.2016.07.003
State	Published - Oct 2016
Externally published	Yes

Keywords

Hybrid aerogels
Alginate
Pectin
Carrageenan
Microparticles
Supercritical fluid technology
KAPPA-CARRAGEENAN OLIGOSACCHARIDES
EMULSIFICATION INTERNAL GELATION
IN-VITRO EVALUATION
MUCOADHESIVE PROPERTIES
CHITOSAN MICROSPHERES
PARTICLES
SYSTEMS
BEADS
QUERCETIN
EMULSIONS

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10.1016/j.ejpb.2016.07.003

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title = "Alginate-based hybrid aerogel microparticles for mucosal drug delivery",

abstract = "The application, of biopolymer aerogels as drug delivery systems (DDS) has gained increased interest during the last decade since these structures have large surface area and accessible pores allowing for high drug loadings. Being biocompatible, biodegradable and presenting low toxicity, polysaccharide-based aerogels are an attractive carrier to be applied in pharmaceutical industry. Moreover, some polysaccharides (e.g. alginate and chitosan) present mucoadhesive properties, an important feature for mucosal drug delivery. This feature allows to extend the contact of DDS with biological membranes, thereby increasing the absorption of drugs through the mucosa. Alginate-based hybrid aerogels in the form of microparticles (",

keywords = "Hybrid aerogels, Alginate, Pectin, Carrageenan, Microparticles, Supercritical fluid technology, KAPPA-CARRAGEENAN OLIGOSACCHARIDES, EMULSIFICATION INTERNAL GELATION, IN-VITRO EVALUATION, MUCOADHESIVE PROPERTIES, CHITOSAN MICROSPHERES, PARTICLES, SYSTEMS, BEADS, QUERCETIN, EMULSIONS",

author = "Goncalves, {V. S. S.} and P. Gurikov and J. Poejo and Matias, {A. A.} and S. Heinrich and Duarte, {C. M. M.} and I. Smirnova",

year = "2016",

month = oct,

doi = "10.1016/j.ejpb.2016.07.003",

language = "English",

volume = "107",

pages = "160--170",

journal = "European Journal of Pharmaceutics and Biopharmaceutics",

issn = "0939-6411",

publisher = "ELSEVIER SCIENCE BV",

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TY - JOUR

T1 - Alginate-based hybrid aerogel microparticles for mucosal drug delivery

AU - Goncalves, V. S. S.

AU - Gurikov, P.

AU - Poejo, J.

AU - Matias, A. A.

AU - Heinrich, S.

AU - Duarte, C. M. M.

AU - Smirnova, I.

PY - 2016/10

Y1 - 2016/10

N2 - The application, of biopolymer aerogels as drug delivery systems (DDS) has gained increased interest during the last decade since these structures have large surface area and accessible pores allowing for high drug loadings. Being biocompatible, biodegradable and presenting low toxicity, polysaccharide-based aerogels are an attractive carrier to be applied in pharmaceutical industry. Moreover, some polysaccharides (e.g. alginate and chitosan) present mucoadhesive properties, an important feature for mucosal drug delivery. This feature allows to extend the contact of DDS with biological membranes, thereby increasing the absorption of drugs through the mucosa. Alginate-based hybrid aerogels in the form of microparticles (

AB - The application, of biopolymer aerogels as drug delivery systems (DDS) has gained increased interest during the last decade since these structures have large surface area and accessible pores allowing for high drug loadings. Being biocompatible, biodegradable and presenting low toxicity, polysaccharide-based aerogels are an attractive carrier to be applied in pharmaceutical industry. Moreover, some polysaccharides (e.g. alginate and chitosan) present mucoadhesive properties, an important feature for mucosal drug delivery. This feature allows to extend the contact of DDS with biological membranes, thereby increasing the absorption of drugs through the mucosa. Alginate-based hybrid aerogels in the form of microparticles (

KW - Hybrid aerogels

KW - Alginate

KW - Pectin

KW - Carrageenan

KW - Microparticles

KW - Supercritical fluid technology

KW - KAPPA-CARRAGEENAN OLIGOSACCHARIDES

KW - EMULSIFICATION INTERNAL GELATION

KW - IN-VITRO EVALUATION

KW - MUCOADHESIVE PROPERTIES

KW - CHITOSAN MICROSPHERES

KW - PARTICLES

KW - SYSTEMS

KW - BEADS

KW - QUERCETIN

KW - EMULSIONS

U2 - 10.1016/j.ejpb.2016.07.003

DO - 10.1016/j.ejpb.2016.07.003

M3 - Article

C2 - 27393563

SN - 0939-6411

VL - 107

SP - 160

EP - 170

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

ER -

Alginate-based hybrid aerogel microparticles for mucosal drug delivery

Abstract

Keywords

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