An improved total synthesis of spermatinamine, an inhibitor of isoprenylcysteine carboxy methyltransferase

Nisar Ullah; Shamsuddeen A. Haladu; Basem Moosa

doi:10.1016/j.tetlet.2010.10.164

An improved total synthesis of spermatinamine, an inhibitor of isoprenylcysteine carboxy methyltransferase

Nisar Ullah^*, Shamsuddeen A. Haladu, Basem Moosa

^*Corresponding author for this work

Advanced Membranes and Porous Materials Center

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

An improved total synthesis of spermatinamine, an inhibitor of the anticancer target, isoprenylcysteine carboxy methyltransferase (Icmt) was accomplished from the commercially available 3,4-dibromo-4-hydroxybenzaldehyde via a high yielding reaction sequence in an overall yield of 31%.

Original language	English (US)
Pages (from-to)	212-214
Number of pages	3
Journal	Tetrahedron Letters
Volume	52
Issue number	2
DOIs	https://doi.org/10.1016/j.tetlet.2010.10.164
State	Published - Jan 12 2011

Keywords

Anticancer drug
Azlactone formation
Icmt inhibitor
Spermatinamine

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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10.1016/j.tetlet.2010.10.164

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title = "An improved total synthesis of spermatinamine, an inhibitor of isoprenylcysteine carboxy methyltransferase",

abstract = "An improved total synthesis of spermatinamine, an inhibitor of the anticancer target, isoprenylcysteine carboxy methyltransferase (Icmt) was accomplished from the commercially available 3,4-dibromo-4-hydroxybenzaldehyde via a high yielding reaction sequence in an overall yield of 31%.",

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AU - Ullah, Nisar

AU - Haladu, Shamsuddeen A.

AU - Moosa, Basem

PY - 2011/1/12

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AB - An improved total synthesis of spermatinamine, an inhibitor of the anticancer target, isoprenylcysteine carboxy methyltransferase (Icmt) was accomplished from the commercially available 3,4-dibromo-4-hydroxybenzaldehyde via a high yielding reaction sequence in an overall yield of 31%.

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KW - Azlactone formation

KW - Icmt inhibitor

KW - Spermatinamine

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An improved total synthesis of spermatinamine, an inhibitor of isoprenylcysteine carboxy methyltransferase

Abstract

Keywords

ASJC Scopus subject areas

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