An infrastructure for ontology-based information systems in biomedicine: Ricordo case study

Sarala M. Wimalaratne; Pierre Grenon; Robert Hoehndorf; Georgios V. Gkoutos; Bernard de Bono

doi:10.1093/bioinformatics/btr662

An infrastructure for ontology-based information systems in biomedicine: Ricordo case study

Sarala M. Wimalaratne^*, Pierre Grenon, Robert Hoehndorf, Georgios V. Gkoutos, Bernard de Bono

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The article presents an infrastructure for supporting the semantic interoperability of biomedical resources based on the management (storing and inference-based querying) of their ontology-based annotations. This infrastructure consists of: (i) a repository to store and query ontology-based annotations; (ii) a knowledge base server with an inference engine to support the storage of and reasoning over ontologies used in the annotation of resources; (iii) a set of applications and services allowing interaction with the integrated repository and knowledge base. The infrastructure is being prototyped and developed and evaluated by the RICORDO project in support of the knowledge management of biomedical resources, including physiology and pharmacology models and associated clinical data.

Original language	English (US)
Article number	btr662
Pages (from-to)	448-450
Number of pages	3
Journal	Bioinformatics
Volume	28
Issue number	3
DOIs	https://doi.org/10.1093/bioinformatics/btr662
State	Published - Feb 2012
Externally published	Yes

ASJC Scopus subject areas

Statistics and Probability
Biochemistry
Molecular Biology
Computer Science Applications
Computational Theory and Mathematics
Computational Mathematics

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abstract = "The article presents an infrastructure for supporting the semantic interoperability of biomedical resources based on the management (storing and inference-based querying) of their ontology-based annotations. This infrastructure consists of: (i) a repository to store and query ontology-based annotations; (ii) a knowledge base server with an inference engine to support the storage of and reasoning over ontologies used in the annotation of resources; (iii) a set of applications and services allowing interaction with the integrated repository and knowledge base. The infrastructure is being prototyped and developed and evaluated by the RICORDO project in support of the knowledge management of biomedical resources, including physiology and pharmacology models and associated clinical data.",

author = "Wimalaratne, {Sarala M.} and Pierre Grenon and Robert Hoehndorf and Gkoutos, {Georgios V.} and {de Bono}, Bernard",

note = "Funding Information: Funding: European Commission, grant agreement number (248502) (RICORDO) and 223920 (VPH NoE) within the 7th Framework Programme.",

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AU - de Bono, Bernard

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An infrastructure for ontology-based information systems in biomedicine: Ricordo case study

Abstract

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