An on-surface Diels–Alder reaction

Jesús Castro-Esteban, Florian Albrecht, Shadi Fatayer, Dolores Pérez, Leo Gross, Diego Peña

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The Diels–Alder reaction is one of the most popular reactions in organic chemistry. However, its use in the field of on-surface synthesis is hampered by the spatial restrictions of this cycloaddition reaction. Herein we selected a cyclic strained triyne to demonstrate an on-surface hexadehydro-Diels–Alder reaction in a single molecule. The reaction was studied in detail by means of atomic force microscopy (AFM) with CO-functionalized tips. Our results pave the way to use this iconic pericyclic reaction for on-surface synthesis, introducing the concept of atom economy in the field.
Original languageEnglish (US)
Pages (from-to)26346-26350
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number50
StatePublished - Dec 6 2021
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis


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