An Overview of Lipid Droplets in Cancer and Cancer Stem Cells

Luca Tirinato; Francesca Pagliari; Tania Limongi; Monica Marini; Andrea Falqui; J. Seco; Patrizio Candeloro; Carlo Liberale; Enzo M. Di Fabrizio

doi:10.1155/2017/1656053

An Overview of Lipid Droplets in Cancer and Cancer Stem Cells

Luca Tirinato, Francesca Pagliari, Tania Limongi, Monica Marini, Andrea Falqui, J. Seco, Patrizio Candeloro, Carlo Liberale, Enzo M. Di Fabrizio

Research output: Contribution to journal › Article › peer-review

162 Scopus citations

Abstract

For decades, lipid droplets have been considered as the main cellular organelles involved in the fat storage, because of their lipid composition. However, in recent years, some new and totally unexpected roles have been discovered for them: (i) they are active sites for synthesis and storage of inflammatory mediators, and (ii) they are key players in cancer cells and tissues, especially in cancer stem cells. In this review, we summarize the main concepts related to the lipid droplet structure and function and their involvement in inflammatory and cancer processes.

Original language	English (US)
Pages (from-to)	1-17
Number of pages	17
Journal	Stem Cells International
Volume	2017
DOIs	https://doi.org/10.1155/2017/1656053
State	Published - Aug 13 2017

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10.1155/2017/1656053

https://repository.kaust.edu.sa/bitstream/10754/625359/1/1656053.pdf

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title = "An Overview of Lipid Droplets in Cancer and Cancer Stem Cells",

abstract = "For decades, lipid droplets have been considered as the main cellular organelles involved in the fat storage, because of their lipid composition. However, in recent years, some new and totally unexpected roles have been discovered for them: (i) they are active sites for synthesis and storage of inflammatory mediators, and (ii) they are key players in cancer cells and tissues, especially in cancer stem cells. In this review, we summarize the main concepts related to the lipid droplet structure and function and their involvement in inflammatory and cancer processes.",

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note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The authors acknowledge financial support from KAUST Baseline Research Funds (BAS/1-1064-01-01 and BAS/1-1066-01-01) to C. Liberale and A. Falqui, respectively, and from KAUST start-up funding (Project no. GR-2010-2320665) to E. Di Fabrizio.",

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AU - Tirinato, Luca

AU - Pagliari, Francesca

AU - Limongi, Tania

AU - Marini, Monica

AU - Falqui, Andrea

AU - Seco, J.

AU - Candeloro, Patrizio

AU - Liberale, Carlo

AU - Di Fabrizio, Enzo M.

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The authors acknowledge financial support from KAUST Baseline Research Funds (BAS/1-1064-01-01 and BAS/1-1066-01-01) to C. Liberale and A. Falqui, respectively, and from KAUST start-up funding (Project no. GR-2010-2320665) to E. Di Fabrizio.

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Y1 - 2017/8/13

N2 - For decades, lipid droplets have been considered as the main cellular organelles involved in the fat storage, because of their lipid composition. However, in recent years, some new and totally unexpected roles have been discovered for them: (i) they are active sites for synthesis and storage of inflammatory mediators, and (ii) they are key players in cancer cells and tissues, especially in cancer stem cells. In this review, we summarize the main concepts related to the lipid droplet structure and function and their involvement in inflammatory and cancer processes.

AB - For decades, lipid droplets have been considered as the main cellular organelles involved in the fat storage, because of their lipid composition. However, in recent years, some new and totally unexpected roles have been discovered for them: (i) they are active sites for synthesis and storage of inflammatory mediators, and (ii) they are key players in cancer cells and tissues, especially in cancer stem cells. In this review, we summarize the main concepts related to the lipid droplet structure and function and their involvement in inflammatory and cancer processes.

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JO - Stem Cells International

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An Overview of Lipid Droplets in Cancer and Cancer Stem Cells

Abstract

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