An overview of mammalian pluripotency

Jun Wu, Takayoshi Yamauchi, Juan Carlos Izpisua Belmonte*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Mammalian pluripotency is the ability to give rise to all somatic cells as well as the germ cells of an adult mammal. It is a unique feature of embryonic epiblast cells, existing only transiently, as cells pass through early developmental stages. By contrast, pluripotency can be captured and stabilized indefinitely in cell culture and can also be reactivated in differentiated cells via nuclear reprogramming. Pluripotent stem cells (PSCs) are the in vitro carriers of pluripotency and they can inhabit discrete pluripotent states depending on the stage at which they were derived and their culture conditions. Here, and in the accompanying poster, we provide a summary of mammalian pluripotency both in vivo and in vitro, and highlight recent and future applications of PSCs for basic and translational research.

Original languageEnglish (US)
Pages (from-to)1644-1648
Number of pages5
JournalDevelopment (Cambridge)
Issue number10
StatePublished - May 15 2016


  • Embryonic stem cells
  • Pluripotency
  • Pluripotent stem cells
  • Reprogramming

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology


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