TY - GEN
T1 - Analysis of different coating thickness on new type of planar interdigital sensors for endotoxin detection
AU - Syaifudin, A. R Mohd
AU - Yu, Paklam
AU - Mukhopadhyay, Subhas Chandra
AU - Gooneratne, Chinthaka Pasan
AU - Kosel, Jürgen
N1 - KAUST Repository Item: Exported on 2020-10-01
PY - 2013/5
Y1 - 2013/5
N2 - New types of planar interdigital sensors have been fabricated on Silicon/Silicon Dioxide (Si/SiO2) wafers. The sensors were coated with pre-cursor silica functionalized with APTES (3-aminopropyltrietoxysilane) at different thicknesses. All sensors were then immobilized with Polymyxin, B (PmB). PmB is an antimicrobial peptide produced by the Gram-positive bacterium-Bacillus, has been immobilized on the coated sensors because of its specific binding properties to endotoxin. Studies were conducted to analyze the effect of different thicknesses of coatings on the sensitivity and selectivity of the sensors. It was observed sensors coated with 3 layers of coating has better sensitivity and selectivity to the target molecules (endotoxin) compared to sensors with 5 layers of coating. The repeatability and stability of the coated sensors were tested by multiple standard endotoxin measurement and it was observed that the sensors give a good reproducibility and stability up to six continuous measurements before the coating degrades. © 2013 IEEE.
AB - New types of planar interdigital sensors have been fabricated on Silicon/Silicon Dioxide (Si/SiO2) wafers. The sensors were coated with pre-cursor silica functionalized with APTES (3-aminopropyltrietoxysilane) at different thicknesses. All sensors were then immobilized with Polymyxin, B (PmB). PmB is an antimicrobial peptide produced by the Gram-positive bacterium-Bacillus, has been immobilized on the coated sensors because of its specific binding properties to endotoxin. Studies were conducted to analyze the effect of different thicknesses of coatings on the sensitivity and selectivity of the sensors. It was observed sensors coated with 3 layers of coating has better sensitivity and selectivity to the target molecules (endotoxin) compared to sensors with 5 layers of coating. The repeatability and stability of the coated sensors were tested by multiple standard endotoxin measurement and it was observed that the sensors give a good reproducibility and stability up to six continuous measurements before the coating degrades. © 2013 IEEE.
UR - http://hdl.handle.net/10754/564714
UR - http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=6555663
UR - http://www.scopus.com/inward/record.url?scp=84882274938&partnerID=8YFLogxK
U2 - 10.1109/I2MTC.2013.6555663
DO - 10.1109/I2MTC.2013.6555663
M3 - Conference contribution
SN - 9781467346221
SP - 1496
EP - 1501
BT - 2013 IEEE International Instrumentation and Measurement Technology Conference (I2MTC)
PB - Institute of Electrical and Electronics Engineers (IEEE)
ER -