Ancient Ethiopian genome reveals extensive Eurasian admixture in Eastern Africa

M. Gallego Llorente; E. R. Jones; Anders Eriksson; V. Siska; K. W. Arthur; J. W. Arthur; M. C. Curtis; J. T. Stock; M. Coltorti; P. Pieruccini; S. Stretton; F. Brock; T. Higham; Y. Park; M. Hofreiter; D. G. Bradley; J. Bhak; R. Pinhasi; A. Manica

doi:10.1126/science.aad2879

Ancient Ethiopian genome reveals extensive Eurasian admixture in Eastern Africa

M. Gallego Llorente, E. R. Jones, Anders Eriksson, V. Siska, K. W. Arthur, J. W. Arthur, M. C. Curtis, J. T. Stock, M. Coltorti, P. Pieruccini, S. Stretton, F. Brock, T. Higham, Y. Park, M. Hofreiter, D. G. Bradley, J. Bhak, R. Pinhasi, A. Manica

Biological, Environmental Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

217 Scopus citations

Abstract

Characterizing genetic diversity in Africa is a crucial step for most analyses reconstructing the evolutionary history of anatomically modern humans. However, historic migrations from Eurasia into Africa have affected many contemporary populations, confounding inferences. Here, we present a 12.5×coverage ancient genome of an Ethiopian male ("Mota") who lived approximately 4500 years ago. We use this genome to demonstrate that the Eurasian backflow into Africa came from a population closely related to Early Neolithic farmers, who had colonized Europe 4000 years earlier. The extent of this backflow was much greater than previously reported, reaching all the way to Central, West, and Southern Africa, affecting even populations such as Yoruba and Mbuti, previously thought to be relatively unadmixed, who harbor 6 to 7% Eurasian ancestry.

Original language	English (US)
Pages (from-to)	820-822
Number of pages	3
Journal	Science
Volume	350
Issue number	6262
DOIs	https://doi.org/10.1126/science.aad2879
State	Published - Oct 8 2015

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Gallego Llorente, M., Jones, E. R., Eriksson, A., Siska, V., Arthur, K. W., Arthur, J. W., Curtis, M. C., Stock, J. T., Coltorti, M., Pieruccini, P., Stretton, S., Brock, F., Higham, T., Park, Y., Hofreiter, M., Bradley, D. G., Bhak, J., Pinhasi, R., & Manica, A. (2015). Ancient Ethiopian genome reveals extensive Eurasian admixture in Eastern Africa. Science, 350(6262), 820-822. https://doi.org/10.1126/science.aad2879

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title = "Ancient Ethiopian genome reveals extensive Eurasian admixture in Eastern Africa",

abstract = "Characterizing genetic diversity in Africa is a crucial step for most analyses reconstructing the evolutionary history of anatomically modern humans. However, historic migrations from Eurasia into Africa have affected many contemporary populations, confounding inferences. Here, we present a 12.5×coverage ancient genome of an Ethiopian male ({"}Mota{"}) who lived approximately 4500 years ago. We use this genome to demonstrate that the Eurasian backflow into Africa came from a population closely related to Early Neolithic farmers, who had colonized Europe 4000 years earlier. The extent of this backflow was much greater than previously reported, reaching all the way to Central, West, and Southern Africa, affecting even populations such as Yoruba and Mbuti, previously thought to be relatively unadmixed, who harbor 6 to 7% Eurasian ancestry.",

author = "{Gallego Llorente}, M. and Jones, {E. R.} and Anders Eriksson and V. Siska and Arthur, {K. W.} and Arthur, {J. W.} and Curtis, {M. C.} and Stock, {J. T.} and M. Coltorti and P. Pieruccini and S. Stretton and F. Brock and T. Higham and Y. Park and M. Hofreiter and Bradley, {D. G.} and J. Bhak and R. Pinhasi and A. Manica",

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Gallego Llorente, M, Jones, ER, Eriksson, A, Siska, V, Arthur, KW, Arthur, JW, Curtis, MC, Stock, JT, Coltorti, M, Pieruccini, P, Stretton, S, Brock, F, Higham, T, Park, Y, Hofreiter, M, Bradley, DG, Bhak, J, Pinhasi, R & Manica, A 2015, 'Ancient Ethiopian genome reveals extensive Eurasian admixture in Eastern Africa', Science, vol. 350, no. 6262, pp. 820-822. https://doi.org/10.1126/science.aad2879

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AU - Gallego Llorente, M.

AU - Jones, E. R.

AU - Eriksson, Anders

AU - Siska, V.

AU - Arthur, K. W.

AU - Arthur, J. W.

AU - Curtis, M. C.

AU - Stock, J. T.

AU - Coltorti, M.

AU - Pieruccini, P.

AU - Stretton, S.

AU - Brock, F.

AU - Higham, T.

AU - Park, Y.

AU - Hofreiter, M.

AU - Bradley, D. G.

AU - Bhak, J.

AU - Pinhasi, R.

AU - Manica, A.

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AB - Characterizing genetic diversity in Africa is a crucial step for most analyses reconstructing the evolutionary history of anatomically modern humans. However, historic migrations from Eurasia into Africa have affected many contemporary populations, confounding inferences. Here, we present a 12.5×coverage ancient genome of an Ethiopian male ("Mota") who lived approximately 4500 years ago. We use this genome to demonstrate that the Eurasian backflow into Africa came from a population closely related to Early Neolithic farmers, who had colonized Europe 4000 years earlier. The extent of this backflow was much greater than previously reported, reaching all the way to Central, West, and Southern Africa, affecting even populations such as Yoruba and Mbuti, previously thought to be relatively unadmixed, who harbor 6 to 7% Eurasian ancestry.

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Ancient Ethiopian genome reveals extensive Eurasian admixture in Eastern Africa

Abstract

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