TY - JOUR
T1 - Archaea from the gut microbiota of humans: Could be linked to chronic diseases?
AU - Mafra, Denise
AU - Ribeiro, Marcia
AU - Fonseca, Larissa
AU - Regis, Bruna
AU - Cardozo, Ludmila F M F
AU - Fragoso Dos Santos, Henrique
AU - Emiliano de Jesus, Hugo
AU - Schultz, Junia
AU - Shiels, Paul G
AU - Stenvinkel, Peter
AU - Rosado, Alexandre S.
N1 - KAUST Repository Item: Exported on 2022-09-14
Acknowledged KAUST grant number(s): BAS/1/1096-01-01
Acknowledgements: Conselho Nacional de Pesquisa (CNPq) and Coordenação de Aperfeiçoamento de Pessoal deNível Superior (CAPES), Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) support Denise Mafra research. ASR and JS were supported by KAUST grant KAUST (BAS/1/1096-01-01).
PY - 2022/8/17
Y1 - 2022/8/17
N2 - Archaea comprise a unique domain of organisms with distinct biochemical and genetic differences from bacteria. Methane-forming archaea, methanogens, constitute the predominant group of archaea in the human gut microbiota, with Methanobrevibacter smithii being the most prevalent. However, the effect of methanogenic archaea and their methane production on chronic disease remains controversial. As perturbation of the microbiota is a feature of chronic conditions, such as cardiovascular disease, neurodegenerative diseases and chronic kidney disease, assessing the influence of archaea could provide a new clue to mitigating adverse effects associated with dysbiosis. In this review, we will discuss the putative role of archaea in the gut microbiota in humans and the possible link to chronic diseases.
AB - Archaea comprise a unique domain of organisms with distinct biochemical and genetic differences from bacteria. Methane-forming archaea, methanogens, constitute the predominant group of archaea in the human gut microbiota, with Methanobrevibacter smithii being the most prevalent. However, the effect of methanogenic archaea and their methane production on chronic disease remains controversial. As perturbation of the microbiota is a feature of chronic conditions, such as cardiovascular disease, neurodegenerative diseases and chronic kidney disease, assessing the influence of archaea could provide a new clue to mitigating adverse effects associated with dysbiosis. In this review, we will discuss the putative role of archaea in the gut microbiota in humans and the possible link to chronic diseases.
UR - http://hdl.handle.net/10754/680474
UR - https://linkinghub.elsevier.com/retrieve/pii/S1075996422001226
U2 - 10.1016/j.anaerobe.2022.102629
DO - 10.1016/j.anaerobe.2022.102629
M3 - Article
C2 - 35985606
SN - 1075-9964
SP - 102629
JO - Anaerobe
JF - Anaerobe
ER -
