Assessment of the EarlyCDT-Lung test as an early biomarker of lung cancer in ever-smokers: A retrospective nested case-control study in two prospective cohorts

Wendy Yi Ying Wu; Zahra Haider; Xiaoshuang Feng; Alicia K. Heath; Anne Tjønneland; Antonio Agudo; Giovanna Masala; Hilary A. Robbins; José María Huerta; Marcela Guevara; Matthias B. Schulze; Miguel Rodriguez-Barranco; Paolo Vineis; Rosario Tumino; Rudolf Kaaks; Renée T. Fortner; Sabina Sieri; Salvatore Panico; Therese Haugdahl Nøst; Torkjel M. Sandanger; Tonje Braaten; Mattias Johansson; Beatrice Melin; Mikael Johansson

doi:10.1002/ijc.34340

Assessment of the EarlyCDT-Lung test as an early biomarker of lung cancer in ever-smokers: A retrospective nested case-control study in two prospective cohorts

Wendy Yi Ying Wu, Zahra Haider, Xiaoshuang Feng, Alicia K. Heath, Anne Tjønneland, Antonio Agudo, Giovanna Masala, Hilary A. Robbins, José María Huerta, Marcela Guevara, Matthias B. Schulze, Miguel Rodriguez-Barranco, Paolo Vineis, Rosario Tumino, Rudolf Kaaks, Renée T. Fortner, Sabina Sieri, Salvatore Panico, Therese Haugdahl Nøst, Torkjel M. SandangerTonje Braaten, Mattias Johansson, Beatrice Melin, Mikael Johansson

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The EarlyCDT-Lung test is a blood-based autoantibody assay intended to identify high-risk individuals for low-dose computed tomography lung cancer screening. However, there is a paucity of evidence on the performance of the EarlyCDT-Lung test in ever-smokers. We conducted a nested case-control study within two prospective cohorts to evaluate the risk-discriminatory performance of the EarlyCDT-Lung test using prediagnostic blood samples from 154 future lung cancer cases and 154 matched controls. Cases were selected from those who had ever smoked and had a prediagnostic blood sample

Original language	English (US)
Pages (from-to)	2002-2010
Number of pages	9
Journal	International Journal of Cancer
Volume	152
Issue number	9
DOIs	https://doi.org/10.1002/ijc.34340
State	Published - May 1 2023
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ijc.34340

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Wu, W. Y. Y., Haider, Z., Feng, X., Heath, A. K., Tjønneland, A., Agudo, A., Masala, G., Robbins, H. A., Huerta, J. M., Guevara, M., Schulze, M. B., Rodriguez-Barranco, M., Vineis, P., Tumino, R., Kaaks, R., Fortner, R. T., Sieri, S., Panico, S., Nøst, T. H., ... Johansson, M. (2023). Assessment of the EarlyCDT-Lung test as an early biomarker of lung cancer in ever-smokers: A retrospective nested case-control study in two prospective cohorts. International Journal of Cancer, 152(9), 2002-2010. https://doi.org/10.1002/ijc.34340

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title = "Assessment of the EarlyCDT-Lung test as an early biomarker of lung cancer in ever-smokers: A retrospective nested case-control study in two prospective cohorts",

abstract = "The EarlyCDT-Lung test is a blood-based autoantibody assay intended to identify high-risk individuals for low-dose computed tomography lung cancer screening. However, there is a paucity of evidence on the performance of the EarlyCDT-Lung test in ever-smokers. We conducted a nested case-control study within two prospective cohorts to evaluate the risk-discriminatory performance of the EarlyCDT-Lung test using prediagnostic blood samples from 154 future lung cancer cases and 154 matched controls. Cases were selected from those who had ever smoked and had a prediagnostic blood sample",

author = "Wu, {Wendy Yi Ying} and Zahra Haider and Xiaoshuang Feng and Heath, {Alicia K.} and Anne Tj{\o}nneland and Antonio Agudo and Giovanna Masala and Robbins, {Hilary A.} and Huerta, {Jos{\'e} Mar{\'i}a} and Marcela Guevara and Schulze, {Matthias B.} and Miguel Rodriguez-Barranco and Paolo Vineis and Rosario Tumino and Rudolf Kaaks and Fortner, {Ren{\'e}e T.} and Sabina Sieri and Salvatore Panico and N{\o}st, {Therese Haugdahl} and Sandanger, {Torkjel M.} and Tonje Braaten and Mattias Johansson and Beatrice Melin and Mikael Johansson",

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Wu, WYY, Haider, Z, Feng, X, Heath, AK, Tjønneland, A, Agudo, A, Masala, G, Robbins, HA, Huerta, JM, Guevara, M, Schulze, MB, Rodriguez-Barranco, M, Vineis, P, Tumino, R, Kaaks, R, Fortner, RT, Sieri, S, Panico, S, Nøst, TH, Sandanger, TM, Braaten, T, Johansson, M, Melin, B & Johansson, M 2023, 'Assessment of the EarlyCDT-Lung test as an early biomarker of lung cancer in ever-smokers: A retrospective nested case-control study in two prospective cohorts', International Journal of Cancer, vol. 152, no. 9, pp. 2002-2010. https://doi.org/10.1002/ijc.34340

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AU - Wu, Wendy Yi Ying

AU - Haider, Zahra

AU - Feng, Xiaoshuang

AU - Heath, Alicia K.

AU - Tjønneland, Anne

AU - Agudo, Antonio

AU - Masala, Giovanna

AU - Robbins, Hilary A.

AU - Huerta, José María

AU - Guevara, Marcela

AU - Schulze, Matthias B.

AU - Rodriguez-Barranco, Miguel

AU - Vineis, Paolo

AU - Tumino, Rosario

AU - Kaaks, Rudolf

AU - Fortner, Renée T.

AU - Sieri, Sabina

AU - Panico, Salvatore

AU - Nøst, Therese Haugdahl

AU - Sandanger, Torkjel M.

AU - Braaten, Tonje

AU - Johansson, Mattias

AU - Melin, Beatrice

AU - Johansson, Mikael

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AB - The EarlyCDT-Lung test is a blood-based autoantibody assay intended to identify high-risk individuals for low-dose computed tomography lung cancer screening. However, there is a paucity of evidence on the performance of the EarlyCDT-Lung test in ever-smokers. We conducted a nested case-control study within two prospective cohorts to evaluate the risk-discriminatory performance of the EarlyCDT-Lung test using prediagnostic blood samples from 154 future lung cancer cases and 154 matched controls. Cases were selected from those who had ever smoked and had a prediagnostic blood sample

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SP - 2002

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JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 9

ER -

Assessment of the EarlyCDT-Lung test as an early biomarker of lung cancer in ever-smokers: A retrospective nested case-control study in two prospective cohorts

Abstract

ASJC Scopus subject areas

UN SDGs

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