TY - JOUR
T1 - Association between Temporal Glycemic Change and Risk of Pancreatic Cancer in Men: A Prospective Cohort Study
AU - Cai, Jie
AU - Chen, Hongda
AU - Lu, Ming
AU - Zhang, Yuhan
AU - Lu, Bin
AU - Luo, Chenyu
AU - Feng, Xiaoshuang
AU - You, Lei
AU - Dai, Min
AU - Zhao, Yupei
N1 - Generated from Scopus record by KAUST IRTS on 2023-09-21
PY - 2022/7/1
Y1 - 2022/7/1
N2 - Hyperglycemia has been reported to increase the risk of pancreatic cancer (PC), while the association between glycemic change and PC risk has rarely been explored. Using data from a prospective cohort study conducted in China since 2006, 138,870 males with available fasting blood glucose (FBG) levels, including 106,632 males with at least two FBG measurements, were analyzed. The associations between FBG (level, change, and stability) and PC incidence were evaluated using Cox proportional hazard regression and restricted cubic splines. Baseline (p = 0.109) and recent (p = 0.070) FBG levels and incident PC were not significantly associated. U-shaped associations were observed between the annual FBG change and PC risk. Compared with stable FBG, participants with annual FBG change rates 0.15 mmol/L had about four-fold (HR, 4.010; 95% CI: 1.920–8.375) and six-fold (HR, 5.897; 95% CI: 2.935–11.848) higher PC risks, respectively. The PC risk increased by 2.5% (HRlinear = 1.025, 95% CI:1.009–1.042) for every 1% increase in the coefficient of variation for FBG. A subgroup analysis of males without diabetes at baseline showed stronger associations. Temporal FBG changes may be an important factor for identifying populations with high PC risks.
AB - Hyperglycemia has been reported to increase the risk of pancreatic cancer (PC), while the association between glycemic change and PC risk has rarely been explored. Using data from a prospective cohort study conducted in China since 2006, 138,870 males with available fasting blood glucose (FBG) levels, including 106,632 males with at least two FBG measurements, were analyzed. The associations between FBG (level, change, and stability) and PC incidence were evaluated using Cox proportional hazard regression and restricted cubic splines. Baseline (p = 0.109) and recent (p = 0.070) FBG levels and incident PC were not significantly associated. U-shaped associations were observed between the annual FBG change and PC risk. Compared with stable FBG, participants with annual FBG change rates 0.15 mmol/L had about four-fold (HR, 4.010; 95% CI: 1.920–8.375) and six-fold (HR, 5.897; 95% CI: 2.935–11.848) higher PC risks, respectively. The PC risk increased by 2.5% (HRlinear = 1.025, 95% CI:1.009–1.042) for every 1% increase in the coefficient of variation for FBG. A subgroup analysis of males without diabetes at baseline showed stronger associations. Temporal FBG changes may be an important factor for identifying populations with high PC risks.
UR - https://www.mdpi.com/2072-6694/14/14/3403
UR - http://www.scopus.com/inward/record.url?scp=85136448561&partnerID=8YFLogxK
U2 - 10.3390/cancers14143403
DO - 10.3390/cancers14143403
M3 - Article
C2 - 35884465
SN - 2072-6694
VL - 14
JO - Cancers
JF - Cancers
IS - 14
ER -
