TY - JOUR
T1 - Association of obesity with inflammation in chronic kidney disease: A cross-sectional study
AU - Ramkumar, Nirupama
AU - Cheung, Alfred K.
AU - Pappas, Lisa M.
AU - Roberts, William L.
AU - Beddhu, Srinivasan
N1 - Generated from Scopus record by KAUST IRTS on 2023-09-20
PY - 2004/1/1
Y1 - 2004/1/1
N2 - As adipose tissue releases inflammatory cytokines, obesity is associated with elevated C-reactive protein (CRP) levels in the general population. We examined the cross-sectional association of body mass index (BMI) with CRP in patients with chronic kidney disease (CKD). Cross-sectional study. Ninety-four CKD patients with varying levels of renal function seen at the University of Utah outpatient renal clinic were studied. Data on demographics (age, gender, race), comorbidity (diabetes mellitus, hypertension, myocardial infarction/angina, cerebrovascular disease, peripheral vascular disease, and smoking) and anthropometry (height and weight) were obtained by patient interview and chart reviews. High-sensitivity CRP was measured by the N-latex assay on a BN II nephelometer. Risk factors of high CRP. In a multivariable logistic regression model, when compared with patients with a BMI < 25, the odds of CRP > 3.0 mg/L were 2.5-fold (95% CI, 1.02 to 5.99) higher in patients with BMI ≥ 30. In a stepwise multiple linear regression model, BMI (regression coefficient [β] = 0.06; 95% CI, 0.03 to 0.1; P
AB - As adipose tissue releases inflammatory cytokines, obesity is associated with elevated C-reactive protein (CRP) levels in the general population. We examined the cross-sectional association of body mass index (BMI) with CRP in patients with chronic kidney disease (CKD). Cross-sectional study. Ninety-four CKD patients with varying levels of renal function seen at the University of Utah outpatient renal clinic were studied. Data on demographics (age, gender, race), comorbidity (diabetes mellitus, hypertension, myocardial infarction/angina, cerebrovascular disease, peripheral vascular disease, and smoking) and anthropometry (height and weight) were obtained by patient interview and chart reviews. High-sensitivity CRP was measured by the N-latex assay on a BN II nephelometer. Risk factors of high CRP. In a multivariable logistic regression model, when compared with patients with a BMI < 25, the odds of CRP > 3.0 mg/L were 2.5-fold (95% CI, 1.02 to 5.99) higher in patients with BMI ≥ 30. In a stepwise multiple linear regression model, BMI (regression coefficient [β] = 0.06; 95% CI, 0.03 to 0.1; P
UR - https://linkinghub.elsevier.com/retrieve/pii/S1051227604001335
UR - http://www.scopus.com/inward/record.url?scp=5444249924&partnerID=8YFLogxK
U2 - 10.1053/j.jrn.2004.07.009
DO - 10.1053/j.jrn.2004.07.009
M3 - Article
SN - 1051-2276
VL - 14
SP - 201
EP - 207
JO - Journal of Renal Nutrition
JF - Journal of Renal Nutrition
IS - 4
ER -
