TY - JOUR
T1 - Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia
AU - Al-Amer, Osama M.
AU - Oyouni, Atif Abdulwahab A.
AU - Alshehri, Mohammed Ali
AU - Alasmari, Abdulrahman
AU - Alzahrani, Othman R.
AU - Aljohani, Saad Ali S.
AU - Alasmael, Noura Salman
AU - Theyab, Abdulrahman
AU - Algahtani, Mohammad
AU - Sadoun, Hadeel Al
AU - Alsharif, Khalaf F.
AU - Hamad, Abdullah
AU - Abdali, Wed A.
AU - Hawsawi, Yousef
N1 - KAUST Repository Item: Exported on 2021-11-26
Acknowledgements: This project was supported by the Deanship of Scientific Research (DSR), University.
PY - 2021/11/15
Y1 - 2021/11/15
N2 - Background Globally, iron-deficiency anemia (IDA) remains a major health obstacle. This health condition has been identified in 47% of pre-school students (aged 0 to 5 years), 42% of pregnant females, and 30% of non-pregnant females (aged 15 to 50 years) worldwide according to the WHO. Environmental and genetic factors play a crucial role in the development of IDA; genetic testing has revealed the association of a number of polymorphisms with iron status and serum ferritin. Aim The current study aims to reveal the association of TMPRSS6 rs141312 and BMP2 rs235756 with the iron status of females in Saudi Arabia. Methods A cohort of 108 female university students aged 18–25 years was randomly selected to participate: 50 healthy and 58 classified as iron deficient. A 3–5 mL sample of blood was collected from each one and analyzed based on hematological and biochemical iron status followed by genotyping by PCR. Results The genotype distribution of TMPRSS6 rs141312 was 8% (TT), 88% (TC) and 4% (CC) in the healthy group compared with 3.45% (TT), 89.66% (TC) and 6.89% (CC) in the iron-deficient group (P = 0.492), an insignificant difference in the allelic distribution. The genotype distribution of BMP2 rs235756 was 8% (TT), 90% (TC) and 2% (CC) in the healthy group compared with 3.45% (TT), 82.76% (TC) and 13.79% (CC) in iron-deficient group (P = 0.050) and was significantly associated with decreased ferritin status (P = 0.050). In addition, TMPRSS6 rs141312 is significantly (P
AB - Background Globally, iron-deficiency anemia (IDA) remains a major health obstacle. This health condition has been identified in 47% of pre-school students (aged 0 to 5 years), 42% of pregnant females, and 30% of non-pregnant females (aged 15 to 50 years) worldwide according to the WHO. Environmental and genetic factors play a crucial role in the development of IDA; genetic testing has revealed the association of a number of polymorphisms with iron status and serum ferritin. Aim The current study aims to reveal the association of TMPRSS6 rs141312 and BMP2 rs235756 with the iron status of females in Saudi Arabia. Methods A cohort of 108 female university students aged 18–25 years was randomly selected to participate: 50 healthy and 58 classified as iron deficient. A 3–5 mL sample of blood was collected from each one and analyzed based on hematological and biochemical iron status followed by genotyping by PCR. Results The genotype distribution of TMPRSS6 rs141312 was 8% (TT), 88% (TC) and 4% (CC) in the healthy group compared with 3.45% (TT), 89.66% (TC) and 6.89% (CC) in the iron-deficient group (P = 0.492), an insignificant difference in the allelic distribution. The genotype distribution of BMP2 rs235756 was 8% (TT), 90% (TC) and 2% (CC) in the healthy group compared with 3.45% (TT), 82.76% (TC) and 13.79% (CC) in iron-deficient group (P = 0.050) and was significantly associated with decreased ferritin status (P = 0.050). In addition, TMPRSS6 rs141312 is significantly (P
UR - http://hdl.handle.net/10754/673767
UR - https://dx.plos.org/10.1371/journal.pone.0257895
UR - http://www.scopus.com/inward/record.url?scp=85119279677&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0257895
DO - 10.1371/journal.pone.0257895
M3 - Article
C2 - 34780475
SN - 1932-6203
VL - 16
SP - e0257895
JO - PLoS ONE
JF - PLoS ONE
IS - 11 November
ER -