Astrocyte-specific expression of aquaporin-9 in mouse brain is increased after transient focal cerebral ischemia

Jérôme Badaut, Lorenz Hirt*, Cristina Granziera, Julien Bogousslavsky, Pierre J. Magistretti, Luca Regli

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

168 Scopus citations


Aquaporin-9 (AQP9) is a new member of the aquaporin family of water-selective channels mainly expressed in liver and testis, presenting the characteristic of also being permeable to various solutes, particularly lactate. Recent data have shown the presence of AQP9 on tanycytes in the rat brain. In the current study, the authors show the expression of AQP9 in astrocytes in the mouse brain and changes in its expression after cerebral ischemia. Indeed, in control mouse, the AQP9 immunolabeling is present on astrocytic processes bordering the subarachnoid space and ventricles. The labeling also is observed on astrocytes in the white matter, hippocampus, hypothalamus, and lateral septum. After focal transient ischemia, an increase of the immunolabeling is detected on astrocytes in periinfarct areas. This AQP9 distribution study in mouse brain suggests a role of AQP9 in water homeostasis in the central nervous system. Furthermore, the overexpression of AQP9 on astrocytes surrounding an ischemic lesion suggests that AQP9 may also play a role in the regulation of postischemia edema and, in view of its permeability to monocarboxylates, in the clearance of lactate from the ischemic focus.

Original languageEnglish (US)
Pages (from-to)477-482
Number of pages6
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number5
StatePublished - 2001
Externally publishedYes


  • Aquaporin-9
  • Brain edema
  • Focal cerebral ischemia
  • Mouse brain
  • Transient middle cerebral artery occlusion
  • Water channel

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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