Abstract
A general and practical process for the conversion of prochiral ketones into the corresponding chiral acetates has been realized. An iron carbonyl complex is reported to catalyze the hydrogenation–dehydrogenation–hydrogenation of prochiral ketones. By merging the iron-catalyzed redox reactions with enantioselective enzymatic acylations a wide range of benzylic, aliphatic and (hetero)aromatic ketones, as well as diketones, were reductively acylated. The corresponding products were isolated with high yields and enantioselectivities. The use of an iron catalyst together with molecular hydrogen as the hydrogen donor and readily available ethyl acetate as acyl donor make this cascade process highly interesting in terms of both economic value and environmental credentials.
Original language | English (US) |
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Pages (from-to) | 1664-1668 |
Number of pages | 5 |
Journal | CHEMSUSCHEM |
Volume | 10 |
Issue number | 8 |
DOIs | |
State | Published - Apr 22 2017 |
Keywords
- cascade catalysis
- chiral alcohols
- enzyme
- kinetic resolution
- racemization
ASJC Scopus subject areas
- Environmental Chemistry
- General Chemical Engineering
- General Materials Science
- General Energy