TY - JOUR
T1 - AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis
AU - Friml, Jiří
AU - Benková, Eva
AU - Blilou, Ikram
AU - Wisniewska, Justyna
AU - Hamann, Thorsten
AU - Ljung, Karin
AU - Woody, Scott
AU - Sandberg, Goran
AU - Scheres, Ben
AU - Jürgens, Gerd
AU - Palme, Klaus
N1 - Funding Information:
We thank Petra Tänzler, Michaela Lehnen, and Thomas Steinmann for technical help. We acknowledge the Arabidopsis Biological Resource Center (Columbus, OH) and Thomas Altman for providing material. We also gratefully acknowledge the ADIS service group for DNA sequencing and ZIGIA (Center for Functional Genomics in Arabidopsis) for the En lines. We are grateful to our colleagues, particularly Leo Gälweiler, Niko Geldner, Matthias Godde, and Kathrin Schrick for critical reading of the manuscript. This work was supported by a fellowship of the Deutscher Akademischer Austauschdienset (J.F.), the Deutsche Forschungsgemeinschaft (Schwerpunktprogramm Phytohormone), the European Communities Biotechnology Programs, the Fonds der Chemischen Industrie, and the INCO-Copernicus Program.
PY - 2002/3/8
Y1 - 2002/3/8
N2 - In contrast to animals, little is known about pattern formation in plants. Physiological and genetic data suggest the involvement of the phytohormone auxin in this process. Here, we characterize a novel member of the PIN family of putative auxin efflux carriers, Arabidopsis PIN4, that is localized in developing and mature root meristems. Atpin4 mutants are defective in establishment and maintenance of endogenous auxin gradients, fail to canalize externally applied auxin, and display various patterning defects in both embryonic and seedling roots. We propose a role for AtPIN4 in generating a sink for auxin below the quiescent center of the root meristem that is essential for auxin distribution and patterning.
AB - In contrast to animals, little is known about pattern formation in plants. Physiological and genetic data suggest the involvement of the phytohormone auxin in this process. Here, we characterize a novel member of the PIN family of putative auxin efflux carriers, Arabidopsis PIN4, that is localized in developing and mature root meristems. Atpin4 mutants are defective in establishment and maintenance of endogenous auxin gradients, fail to canalize externally applied auxin, and display various patterning defects in both embryonic and seedling roots. We propose a role for AtPIN4 in generating a sink for auxin below the quiescent center of the root meristem that is essential for auxin distribution and patterning.
UR - http://www.scopus.com/inward/record.url?scp=18344379498&partnerID=8YFLogxK
U2 - 10.1016/S0092-8674(02)00656-6
DO - 10.1016/S0092-8674(02)00656-6
M3 - Article
C2 - 11893337
AN - SCOPUS:18344379498
SN - 0092-8674
VL - 108
SP - 661
EP - 673
JO - Cell
JF - Cell
IS - 5
ER -