Bayesian Inference for Duplication-Mutation with Complementarity Network Models

Ajay Jasra, Adam Persing, Alexandros Beskos, Kari Heine, Maria De Iorio

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


We observe an undirected graph G without multiple edges and self-loops, which is to represent a protein-protein interaction (PPI) network. We assume that G evolved under the duplication-mutation with complementarity (DMC) model from a seed graph, G0, and we also observe the binary forest Γ that represents the duplication history of G. A posterior density for the DMC model parameters is established, and we outline a sampling strategy by which one can perform Bayesian inference; that sampling strategy employs a particle marginal Metropolis-Hastings (PMMH) algorithm. We test our methodology on numerical examples to demonstrate a high accuracy and precision in the inference of the DMC model's mutation and homodimerization parameters.
Original languageEnglish (US)
JournalJournal of Computational Biology
Issue number11
StatePublished - Jan 1 2015
Externally publishedYes


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