TY - JOUR
T1 - Benchmarking the Performance of Electropolymerized Poly(3,4-ethylenedioxythiophene) Electrodes for Neural Interfacing
AU - Nikiforidis, Georgios
AU - Wustoni, Shofarul
AU - Routier, Cyril
AU - Hama, Adel
AU - Koklu, Anil
AU - Saleh, Abdulelah
AU - Steiner, Nadia
AU - Druet, Victor
AU - Fiumelli, Hubert
AU - Inal, Sahika
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): OSR-2015-Sensors-2719
Acknowledgements: The authors thank Prof. Pierre J. Magistretti and his team members at King Abdullah University of Science and Technology (KAUST) for supporting the preparation of neuronal cell culture. C.R. acknowledges the KAUST VRSP scholarship. This work was supported by KAUST Office of Sponsored Research (OSR) under Award No. OSR-2015-Sensors-2719.
PY - 2020/8/21
Y1 - 2020/8/21
N2 - The development of electronics adept at interfacing with the nervous system is an ever-growing effort, leading to discoveries in fundamental neuroscience applied in clinical setting. Highly capacitive and electrochemically stable electronic materials are paramount for these advances. A systematic study is presented where copolymers based on 3,4-ethylenedioxythiophene (EDOT) and its hydroxyl-terminated counterpart (EDOTOH) are electropolymerized in an aqueous solution in the presence of various counter anions and additives. Amongst the conducting materials developed, the copolymer p(EDOT-ran-EDOTOH) doped with perchlorate in the presence of ethylene glycol shows high specific capacitance (105 F g-1 ), and capacitance retention (85%) over 1000 galvanostatic charge-discharge cycles. A microelectrode array-based on this material is fabricated and primary cortical neurons are cultured therein for several days. The microelectrodes electrically stimulate targeted neuronal networks and record their activity with high signal-to-noise ratio. The stability of charge injection capacity of the material is validated via long-term pulsing experiments. While providing insights on the effect of additives and dopants on the electrochemical performance and operational stability of electropolymerized conducting polymers, this study highlights the importance of high capacitance accompanied with stability to achieve high performance electrodes for biological interfacing.
AB - The development of electronics adept at interfacing with the nervous system is an ever-growing effort, leading to discoveries in fundamental neuroscience applied in clinical setting. Highly capacitive and electrochemically stable electronic materials are paramount for these advances. A systematic study is presented where copolymers based on 3,4-ethylenedioxythiophene (EDOT) and its hydroxyl-terminated counterpart (EDOTOH) are electropolymerized in an aqueous solution in the presence of various counter anions and additives. Amongst the conducting materials developed, the copolymer p(EDOT-ran-EDOTOH) doped with perchlorate in the presence of ethylene glycol shows high specific capacitance (105 F g-1 ), and capacitance retention (85%) over 1000 galvanostatic charge-discharge cycles. A microelectrode array-based on this material is fabricated and primary cortical neurons are cultured therein for several days. The microelectrodes electrically stimulate targeted neuronal networks and record their activity with high signal-to-noise ratio. The stability of charge injection capacity of the material is validated via long-term pulsing experiments. While providing insights on the effect of additives and dopants on the electrochemical performance and operational stability of electropolymerized conducting polymers, this study highlights the importance of high capacitance accompanied with stability to achieve high performance electrodes for biological interfacing.
UR - http://hdl.handle.net/10754/664767
UR - https://onlinelibrary.wiley.com/doi/abs/10.1002/mabi.202000215
U2 - 10.1002/mabi.202000215
DO - 10.1002/mabi.202000215
M3 - Article
C2 - 32820588
SN - 1616-5187
SP - 2000215
JO - Macromolecular Bioscience
JF - Macromolecular Bioscience
ER -