Beyond early development: Xenopus as an emerging model for the study of regenerative mechanisms

Caroline W. Beck, Juan Carlos Izpisúa Belmonte, Bea Christen

Research output: Contribution to journalReview articlepeer-review

126 Scopus citations


While Xenopus is a well-known model system for early vertebrate development, in recent years, it has also emerged as a leading model for regeneration research. As an anuran amphibian, Xenopus laevis can regenerate the larval tail and limb by means of the formation of a proliferating blastema, the lens of the eye by transdifferentiation of nearby tissues, and also exhibits a partial regeneration of the postmetamorphic froglet forelimb. With the availability of inducible transgenic techniques for Xenopus, recent experiments are beginning to address the functional role of genes in the process of regeneration. The use of soluble inhibitors has also been very successful in this model. Using the more traditional advantages of Xenopus, others are providing important lineage data on the origin of the cells that make up the tissues of the regenerate. Finally, transcriptome analyses of regenerating tissues seek to identify the genes and cellular processes that enable successful regeneration.

Original languageEnglish (US)
Pages (from-to)1226-1248
Number of pages23
JournalDevelopmental Dynamics
Issue number6
StatePublished - Jun 2009
Externally publishedYes


  • Blastema
  • Epimorphic
  • Hsp70
  • Lens
  • Limb
  • Regeneration
  • Tail
  • Transcriptome
  • Transdifferentiation
  • Xenopus

ASJC Scopus subject areas

  • Developmental Biology


Dive into the research topics of 'Beyond early development: Xenopus as an emerging model for the study of regenerative mechanisms'. Together they form a unique fingerprint.

Cite this