TY - JOUR
T1 - Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells
AU - Croissant, Jonas
AU - Fatieiev, Yevhen
AU - Julfakyan, Khachatur
AU - Lu, Jie
AU - Emwas, Abdelhamid
AU - Anjum, Dalaver H.
AU - Omar, Haneen
AU - Tamanoi, Fuyuhiko
AU - Zink, Jeffrey
AU - Khashab, Niveen M.
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: The authors gratefully acknowledge King Abdullah University of
Science and Technology and the University of California, Los
Angeles for the support of this work.
PY - 2016/6/30
Y1 - 2016/6/30
N2 - We describe biodegradable mesoporous hybrid NPs in the presence of proteins, and its application for drug delivery. We synthesized oxamide-phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of silica source which had a remarkably high organic content with a high surface area. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt%), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.
AB - We describe biodegradable mesoporous hybrid NPs in the presence of proteins, and its application for drug delivery. We synthesized oxamide-phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of silica source which had a remarkably high organic content with a high surface area. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt%), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.
UR - http://hdl.handle.net/10754/612998
UR - http://doi.wiley.com/10.1002/chem.201601714
UR - http://www.scopus.com/inward/record.url?scp=84977550437&partnerID=8YFLogxK
U2 - 10.1002/chem.201601714
DO - 10.1002/chem.201601714
M3 - Article
C2 - 27258139
SN - 0947-6539
VL - 22
SP - 14806
EP - 14811
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 42
ER -
