TY - JOUR
T1 - Biomaterials-based nanofiber scaffold: Targeted and controlled carrier for cell and drug delivery
AU - Garg, Tarun
AU - Rath, Goutam
AU - Goyal, Amit K.
N1 - Generated from Scopus record by KAUST IRTS on 2023-10-12
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Nanofiber scaffold formulations (diameter less than 1000-nm) were successfully used to deliver the drug/cell/gene into the body organs through different routes for an effective treatment of various diseases. Various fabrication methods like drawing, template synthesis, fiber-mesh, phase separation, fiber-bonding, self-assembly, melt-blown, and electrospinning are successfully used for fabrication of nanofibers. These formulations are widely used in various fields such as tissue engineering, drug delivery, cosmetics, as filter media, protective clothing, wound dressing, homeostatic, sensor devices, etc. The present review gives a detailed account on the need of the nanofiber scaffold formulation development along with the biomaterials and techniques implemented for fabrication of the same against innumerable diseases. At present, there is a huge extent of research being performed worldwide on all aspects of biomolecules delivery. The unique characteristics of nanofibers such as higher loading efficiency, superior mechanical performance (stiffness and tensile strength), controlled release behavior, and excellent stability helps in the delivery of plasmid DNA, large protein drugs, genetic materials, and autologous stem-cell to the target site in the future.
AB - Nanofiber scaffold formulations (diameter less than 1000-nm) were successfully used to deliver the drug/cell/gene into the body organs through different routes for an effective treatment of various diseases. Various fabrication methods like drawing, template synthesis, fiber-mesh, phase separation, fiber-bonding, self-assembly, melt-blown, and electrospinning are successfully used for fabrication of nanofibers. These formulations are widely used in various fields such as tissue engineering, drug delivery, cosmetics, as filter media, protective clothing, wound dressing, homeostatic, sensor devices, etc. The present review gives a detailed account on the need of the nanofiber scaffold formulation development along with the biomaterials and techniques implemented for fabrication of the same against innumerable diseases. At present, there is a huge extent of research being performed worldwide on all aspects of biomolecules delivery. The unique characteristics of nanofibers such as higher loading efficiency, superior mechanical performance (stiffness and tensile strength), controlled release behavior, and excellent stability helps in the delivery of plasmid DNA, large protein drugs, genetic materials, and autologous stem-cell to the target site in the future.
UR - http://www.tandfonline.com/doi/full/10.3109/1061186X.2014.992899
UR - http://www.scopus.com/inward/record.url?scp=84923356589&partnerID=8YFLogxK
U2 - 10.3109/1061186X.2014.992899
DO - 10.3109/1061186X.2014.992899
M3 - Article
SN - 1061-186X
VL - 23
SP - 202
EP - 221
JO - Journal of Drug Targeting
JF - Journal of Drug Targeting
IS - 3
ER -